Publications

  Link to PubMed

2016

Landry-Voyer AM, Bilodeau S, Bergeron D, Dionne KL, Port SA, Rouleau C, Boisvert FM, Kehlenbach RH, Bachand F (2016). Human PDCD2L is an export substrate of CRM1 that associates with 40S ribosomal subunit precursors. Mol. Cell Biol. 36, 3019-3032

Port SA, Mendes A, Valkova C, Spillner C, Fahrenkrog B, Kaether C, and Kehlenbach RH (2016). The oncogenic fusion proteins SET-Nup214 and sequestosome-1 (SQSTM1)-Nup214 form dynamic nuclear bodies and differentially affect nuclear protein- and poly(A)+ RNA export. J. Biol. Chem. 291, 23068-23083

Wallbach M, Escobar JD, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, and Oetjen E (2016). Distinct functions of the dual leucine zipper kinase depending on its subcellular localization. Cell Signal. 28, 272-283

Kehlenbach RH and Port SA (2016). Analysis of CRM1-dependent nuclear export in permeabilized cells. Methods Mol Biol. 1411, 489-501

Pfaff J, Rivera Monroy, J, Jamieson, C, Rajanala, K, Vilardi, F, Schwappach B, and Kehlenbach RH (2016). Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane. J Cell Sci. 129, 502-516

2015

Monecke, T, Dickmanns, A, Weiss, MS, Port, SA, Kehlenbach RH and Ficner R (2015). Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1–RanGTP–SPN1–Nup214 quaternary nuclear export complex. Acta Crystallogr. F. 71, 1481-1487

Port, SA, Monecke, T, Dickmanns, A, Spillner, C, Hofele, R, Urlaub, H, Ficner, R, and Kehlenbach, RH (2015). Structural and functional characterization of CRM1-Nup214 interactions reveals multiple FG-binding sites involved in nuclear export. Cell Rep. 13, 690-702

Dickmanns, A, Kehlenbach, RH, and Fahrenkrog, B. (2015). Nuclear pore complexes and nucleocytoplasmic transport: from structure to function to disease. Int. Rev. Cell Mol. Biol. 320, 171-233

Halder K, Dölker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubmüller H, and Neumann, H. (2015). MD Simulations and FRET Reveal an Environment-Sensitive Conformational Plasticity of Importin-β. Biophys J. 109, 277-286

2014

Kimura M, Thakar K, Karaca S, Imamoto N, and Kehlenbach R.H. (2014). Novel approaches for the identification of nuclear transport receptor substrates. Methods Cell Biol. 122, 353-378.

Furuta M, Kose S, Kehlenbach R.H, and Imamoto N. (2014). Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions. Methods Cell Biol. 122, 331-352.

Frohnert, C., Hutten, S., Wälde, S., Nath, A., and Kehlenbach, R.H. (2014). Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase. PLoS One. 9(2):e88887.

2013

Schulz, O., Pieper, C., Clever, M., Pfaff, J., Ruhlandt, A., Kehlenbach, R.H., Wouters, F.S., Großhans, J., Bunt, G., and Enderlein, J. (2013). Resolution doubling in fluorescence microscopy with confocal spinning-disk image scanning microscopy. Proc. Natl. Acad. Sci. USA. 110, 21000-21005.

Snow, C. J., Dar, A., Dutta, A., Kehlenbach, R.H. and Paschal, B.M. (2013). Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport. J. Cell Biol. 201, 541-557.

Roloff, S., Spillner, C., and Kehlenbach, R.H. (2013). Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1. J. Biol. Chem. 288, 3952-3963.

Thakar, K., Karaca, S., Port, S. A., Urlaub, H. and Kehlenbach, R. H. (2013). Identification of CRM1-dependent nuclear export cargoes using quantitative mass spectrometry. Mol. Cell. Proteomics. 12, 664-678.

Ehlers, C., Schirmer, S., Kehlenbach, R.H., Hauber, J. and Chemnitz, J. (2013). Posttranscriptional regulation of CD83 expression 1 by AUF1 proteins. Nucleic Acids Res. 41, 206-219.

2012

Malik, P., Tabarraei, A.,  Kehlenbach, R.H., Korfali, N., Iwasawa, R., Graham, S.V., and Schirmer, E.C. (2012). Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways. J. Biol. Chem. 287, 12277-12292.

Wälde, S., Thakar, K., Hutten, S., Spillner, C., Nath, A. Rothbauer, U., Wiemann, S., and Kehlenbach, R.H. (2012). The nucleoporin Nup358/RanBP2 promotes nuclear import in a cargo- and transport receptor-specific manner. Traffic. 13, 218-233.

Waldmann, I, Spillner, C., and Kehlenbach, R.H. (2012). The nucleoporin like protein NLP1/hCG1 promotes CRM1-dependent nuclear protein export. J. Cell Science. 124, 144-154.

2011

Hamada, M., Haeger, A., Jeganathan, K. B., van Ree, J. H., Malureanu, L., Wälde, S., Joseph, J., Kehlenbach, R. H., and van Deursen, J. M. (2011). Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J. Cell Biol. 194, 597-612.

Pieper, D., Schirmer, S., Prechtel, A. T., Kehlenbach, R. H., Hauber, J., and Chemnitz, J. (2011). Functional characterization of the HuR:CD83 mRNA interaction. PLoS One 6, e23290.

2010

Wälde, S. and Kehlenbach, R.H. (2010). The Part and the Whole: functions of nucleoporins in nucleocytoplasmic transport. Trends Cell Biol. 20, 461-469.

Hilliard, M, Frohnert, C., Spillner, C., Nath, A.,, Lampe, T., Marcone, S., Fitzgerald., D., and Kehlenbach, R.H. (2010). The anti-inflammatory prostaglandin 15-Deoxy-D12,14PGJ2 inhibits CRM1-dependent nuclear protein export. J. Biol. Chem. 285, 22202-22210.

Huenniger, K. Krämer, A., Soom, M., Chang, I., Köhler, M., Depping, R., Kehlenbach, R.H., and Kaether, C. (2010). Notch1 signaling is mediated by importins alpha 3, 4 and 7. Cell. Mol. Life Sciences 67, 3187-3196.

2009

Antony, P.,  Maentele, S.,  Mollenkopf, P.,  Boy, J., Kehlenbach, R.H., Riess, O., and Schmidt, T. (2009). Identification and functional dissection of localization signals within ataxin-3. Neurobiol Dis, 36, 280-292.

Hutten, S., Wälde, S., Spillner, C., Hauber, J. and Kehlenbach, R. H. (2009). The nuclear pore component Nup358 promotes transportin-dependent nuclear import. J. Cell Science. 122, 1100-1110.

Kehlenbach, R.H. (2009). Nucleocytoplasmic transport: players, signals, regulators. In: Kehlenbach R.H., ed. Nuclear Transport. Austin: Landes Bioscience.

2008

Hutten S., Flotho, A., Melchior, F., and Kehlenbach, R.H.  (2008). The Nup358-RanGAP complex is required for efficient importin a/b-dependent nuclear import. Mol. Biol. Cell.19, 2300-2310.

2007

Waldmann, I., Wälde, S. and Kehlenbach, R.H. (2007). Nuclear import of c-Jun is mediated by multiple transport receptors. J. Biol. Chem. 282: 27685-27692.

Hutten, S. and Kehlenbach, R.H. (2007). CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol. 17: 193-201.

Fries, B., Heukeshoven, J., Hauber, I.,Gruttner, C., Stocking, C., Kehlenbach, R.H., Hauber, J., Chemnitz, J. (2007). Analysis of Nucleocytoplasmic Trafficking of the HuR Ligand APRIL and Its Influence on CD83 Expression. J. Biol. Chem. 282: 4504-4515.

2006

Hutten, S. and Kehlenbach, R.H. (2006). Nup214 is required for CRM1-dependent nuclear protein export in vivo. Mol. Cell. Biol. 26: 6772-6785.

Arnold, A, Nath, A., Hauber, J. und Kehlenbach, R.H. (2006). Multiple importins function as nuclear transport receptors for the Rev protein of the human immunodeficiency virus type 1. J. Biol. Chem. 281: 20883-20890.

Schütz, S., Chemnitz, J, Frohme, M., Hauber, J., und Kehlenbach, R.H. (2006). Stimulated expression of mRNAs in activated T cells depends on a functional CRM1 nuclear export pathway. J. Mol. Biol. 358, 997-1009.

Prechtel, AT, Chemnitz, J., Schirme, S, Langbein-Detsch, I, Stülke, J., Dabauvalle, M.C., Kehlenbach, R.H., und Hauber, J. (2006). Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element. J. Biol. Chem. 281:10912-25.

Arnold, A, Nath, A., Wohlwend, D. und Kehlenbach, R.H. (2006). Transportin is a major nuclear import receptor for c-Fos: a novel mode of cargo-interaction. J. Biol. Chem. 281, 5492-5499.

-2005

Kehlenbach, R.H. and Paschal, B.M. (2005). Analysis of nuclear protein transport in vitro. Cell Biology: A Laboratory Handbook. 3rd Edition. J. Celis (Editor). Elsevier. Vol. 2, 267-276.

Kehlenbach, R.H. (2003) In vitro analysis of nuclear mRNA export using molecular beacons for target detection. Nucleic Acids Res, 31, e64

Kehlenbach, R.H. and Gerace, L. (2002) Analysis of nuclear protein import and export in vitro using fluorescent cargoes. Methods Mol Biol, 189, 231-245.

Klemke, M., Kehlenbach, R.H. and Huttner, W.B. (2001). Two overlapping reading frames in a single exon encode interacting proteins-a novel way of gene usage. Embo J, 20, 3849-3860.

Kehlenbach, R.H., Assheuer, R., Kehlenbach, A., Becker, J. and Gerace, L. (2001). Stimulation of Nuclear Export and Inhibition of Nuclear Import by a Ran Mutant Deficient in Binding to Ran-binding Protein 1. J Biol Chem, 276, 14524-14531.

Pasolli, H.A., Klemke, M., Kehlenbach, R.H., Wang, Y. and Huttner, W.B. (2000). Characterization of the extra-large G protein alpha -subunit XLas. I. Tissue distribution and subcellular localization. J Biol Chem, 275, 33622-33632.

Klemke, M., Pasolli, H.A., Kehlenbach, R.H., Offermanns, S., Schultz, G. and Huttner, W.B. (2000) Characterization of the extra-large G protein alpha -subunit XLa s. II. Signal transduction properties. J Biol Chem, 275, 33633-33640.

Guan, T., Kehlenbach, R.H., Schirmer, E.C., Kehlenbach, A., Fan, F., Clurman, B.E., Arnheim, N. and Gerace, L. (2000). Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. Mol. Cell Biol., 20, 5619-5630.

Kehlenbach, R.H. and Gerace, L. (2000) Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro. J. Biol. Chem., 275, 17848-17856.

Kehlenbach, R.H., Dickmanns, A., Kehlenbach, A., Guan, T. and Gerace, L. (1999). A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. J. Cell. Biol, 145, 645-657.

Kehlenbach, R.H., Dickmanns, A. and Gerace, L. (1998) Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT in vitro. J. Cell Biol., 141, 863-874.

Huttner, W.B., Ohashi, M., Kehlenbach, R.H., Barr, F.A., Bauerfeind, R., Bräunling, O., Corbeil, D., Hannah, M., Pasolli, H.A., Schmidt, A. et al. (1995) Biogenesis of neurosecretory vesicles. Cold Spring Harb Symp Quant Biol, 60, 315-327.

Kehlenbach, R.H., Matthey, J. and Huttner, W.B. (1994). XLas is a new type of G protein. Nature, 372, 804-809.

Leyte, A., Barr, F.A., Kehlenbach, R.H. and Huttner, W.B. (1992). Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation. Embo J, 11, 4795-4804.

Zakut, H., Ehrlich, G., Ayalon, A., Prody, C.A., Malinger, G., Seidman, S., Ginzberg, D., Kehlenbach, R.H. and Soreq, H. (1990). Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas. J Clin Invest, 86, 900-908.