Publications

since 2003

2017

  • Callegari, S., Oeljeklaus, S., Warscheid, B., Dennerlein S., Thumm, M., Rehling, P.*, and Dudek, J*. (2017) Phospho-ubiquitin-Parkin complex as a marker for mitophagy signaling. Autophagy 13: 201-211.

  • Guentsch, A., Beneke, A., Swain, L., Farhat, K., Nagarajan, S., Wielockx, B., Dudek, J., Rehling, P., Zieseniss, A., Jatho, A., Chong, M., Santos, C., Shah, A.M., and Katschinski, D.M. (2017) PHD2 is a regulator for glycolytic reprogramming in macrophages. Mol. Cell. Biol. 37, 1-17

  • Schendzielorz, A.B., Schulz, C., Lytovchenko, O., Clancy, A., Guiard, B., Ieva, R., van der Laan, M., and Rehling, P. (2017) Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation. J. Cell Biol. 216:83-92

  • Denkert, N., Schendzielorz, A.B., Barbot, M., Versemann, L., Richter, F., Rehling, P.*, and Meinecke, M.* (2017) Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import. eLife doi: 10.7554/eLife.28324.

  • Dennerlein, S., Wang, C., and Rehling, P. (2017) Plasticity of mitochondrial translation. Trends Cell. Biol. 27: 712–721

 

2016

  • Richter-Dennerlein, R., Oeljeklaus, S., Lorenzi, I., Ronsör, C., Bareth, B., Schendzielorz, AB., Wang, C., Warscheid, B., Rehling, P., Dennerlein, S. (2016) Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell 167, 471-483

  • Lorenzi, I., Oeljeklaus, S., Ronsör, C., Bareth, B., Warscheid, B., Rehling, P., Dennerlein, S. (2016) The ribosome-associated Mba1 escorts Cox2 from insertion machinery to maturing assembly intermediates. Mol Cell Biol. 36, 2782–2793

  • Bareth, B., Nikolov, M., Lorenzi, I., Hildenbeutel, M., Mick, D.U., Helbig, C., Urlaub, H., Ott, M., Rehling, P., Dennerlein, S. (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell 27, 1570-80

  • Levchenko, M., Römpler, K., Wuttke, J.M., Schmidt, B., Neifer, K., Juris, L., Wissel, M. Rehling, P., Deckers, M. (2016)  Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. BBA Mol. Cell Res. 1863, 1624-32

  • Heininger, A. U., Hackert, P., Andreou, A. Z., Boon, K. L., Memet, I., Prior, M., Clancy, A., Schmidt, B., Urlaub, H., Schleiff, E., Sloan, K. E., Deckers, M., Lührmann, R., Enderlein, J., Klostermeier, D., Rehling, P., Bohnsack, M. T. (2016) Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biol, 13, 320-30.

  • Dudek, J., Cheng, I.F., Chowdhury, A., Wozny, K., Balleininger, M., Reinhold, R., Grunau, S., Callegari, S., Toischer, K., Wanders, R.J., Hasenfuß, G., Brügger, B., Guan, K., Rehling, P. (2015) Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med. 8, 139-54

 

2015

  • Richter-Dennerlein, R., Dennerlein, S., Rehling, P. (2015) Integrating mitochondrial translation into the cellular context. Nat. Rev. Mol. Cell Biol. 16, 586-92

  • Dennerlein, S., Oeljeklaus, S., Jans, D., Hellwig, C., Bareth, B., Jakobs, S., Deckers, M., Warscheid, B., Rehling, P. (2015), MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly. Cell Rep. 12, 1644-1655

  • Pacheu-Grau, P., Bareth, B., Dudek, J., Juris, L., Vögtle, F.-N., Wissel, M., Leary, S., Dennerlein, S., Rehling, P., Deckers, M. (2015), Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. Cell Metabolism 21, 823-833

  • Melin, J., Kilisch, M., Neumann, P., Lytovchenko, O., Gomkale, R., Schendzielorz, A., Schmidt, B., Liepold, T., Ficner, R., Jahn, O., Rehling, P., Schulz, C. (2015), A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria. Biochim. Biophys. Acta 1850, 1850-9

  • Schulz, C., Schendzielorz, A., Rehling, P. (2015), Unlocking the presequence import pathway. Trends Cell. Biol. 25, 265-275

  • Dennerlein, S., Rehling, P. (2015), Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance. J. Cell Sci. 128, 833-837

2014

  • Schulz, C., Rehling, P. (2014), Cell Biology. Powering the cell cycle. Science 346, 1059-1060

  • Gornicka, A., Bragoszewski, P., Chroscicki, P., Wenz, L.S., Schulz, C., Rehling, P., Chacinska, A. (2014), A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Mol. Biol. Cell 25, 3999-4009

  • Lytovchenko, O., Naumenko, N., Oeljeklaus, S., Schmidt, B., von der Malsburg, K., Deckers, M., Warscheid, B., van der Laan, M., Rehling, P. (2014), The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase. EMBO J. 33, 1624-38

  • Pfanner, N., van der Laan, M., Amati, P., Capaldi, R. A., Caudy, A. A., Chacinska, A., Darshi, M., Deckers, M., Hoppins, S., Icho, T., Jakobs, S., Ji, J., Kozjak-Pavlovic, V., Meisinger, C., Odgren, P. R., Park, S. K., Rehling, P., Reichert, A. S., Sheikh, M. S., Taylor, S. S., Tsuchida, N., van der Bliek, A. M., van der Klei, I. J., Weissman, J. S., Westermann, B., Zha, J., Neupert, W., Nunnari, J. (2014), Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J. Cell. Biol. 204, 1083-1086

  • Melin, J., Schulz, C., Wrobel, L., Bernhard, O., Chacinska, A., Jahn, O., Schmidt, B., Rehling, P. (2014), Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix. Mol. Cell Biol. 34, 3473-85

  • Schulz, C., Rehling, P. (2014), Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation.. Nat. Commun. 5, 4349

2013

  • Dudek, J., Rehling, P., van der Laan, M. (2013), Mitochondrial protein import: Common principles and physiological networks. Biochim. Biophys. Acta 1833, (2), 274-285

  • Bareth, B., Dennerlein, S., Mick, D.U., Nikolov, M., Urlaub, H., Rehling, P. (2013), The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Mol. Cell. Biol. 33, 4128-4137

  • Welter, E., Montino, M., Reinhold, R., Schlotterhose, P., Krick, R., Dudek, J., Rehling, P., Thumm ,M. (2013), Uth1 is a mitochondrial inner membrane protein dispensable for post-log phase and rapamycin-induced mitophagy. FEBS J. 280, 4970-4982

  • Dudek, J., Cheng, I.F., Balleininger, M., Vaz, F.M., Streckfuss-Bömeke, K., Hübscher, D., Vukotic, M., Wanders, R.J., Rehling, P., Guan, K. (2013), Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome. Stem Cell Res. 11, 806-819

  • Jans, D.C., Wurm, C.A., Riedel, D., Wenzel, D., Stagge, F., Deckers, M., Rehling, P., Jakobs, S. (2013), STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria. Proc Natl Acad Sci U S A. 110, 8936-8941

  • Lytovchenko, O., Melin, J., Schulz, C., Kilisch, M., Hutu, D.P., Rehling, P. (2013), Signal recognition initiates reorganization of the presequence translocase during protein import. EMBO J. 32, 886-898

2012

  • Vukotic, M., Oeljeklaus, S., Wiese, S., Vögtle, F.N., Meisinger, C., Meyer, H.E., Zieseniss, A., Katschinski, D.M., Jans, D.C., Jakobs, S., Warscheid, B., Rehling, P., Deckers, M. (2012), Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex. Cell Metab. 15, (3), 336-347

  • Keil, M., Bareth, B., Woellhaf, M.W., Peleh, V., Prestele, M., Rehling, P., Herrmann, J.M. (2012), Oxa1-ribosome complexes coordinate the assembly of cytochrome c oxidase in mitochondria. J. Biol. Chem. 287, (41), 34484-34493

  • Reinhold, R., Krüger, V., Meinecke, M., Schulz, C., Schmidt, B., Grunau, S.D., Guiard, B., Wiedemann, N., van der Laan, M., Wagner, R., Rehling, P., Dudek, J. (2012), The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Mol. Cell. Biol. 32, (24), 5009-5021

  • Krüger, V., Deckers, M., Hildenbeutel, M., van der Laan, M., Hellmers, M., Dreker, C., Preuss, M., Herrmann, J.M., Rehling, P., Wagner, R., Meinecke, M. (2012), The mitochondrial oxidase assembly protein1 (Oxa1) insertase forms a membrane pore in lipid bilayers. J. Biol. Chem. 287, 33314-33326

  • Mick, D. U., Dennerlein, S., Wiese, H, Reinhold, R., Pacheu-Grau, D., Lorenzi, I., Sasarman, F., Weraarpachai, W., Shoubridge, E. A., Warscheid, B. and Rehling, P. (2012), MITRAC Links Mitochondrial Protein Translocation to Respiratory-Chain Assembly and Translational Regulation. Cell 151, 1528–1541

2011

  • Reinhold, R., Bareth, B., Balleininger, M., Wissel, M., Rehling, P., Mick, D.U. (2011), Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Hum. Mol. Genet. 20, (12), 2379-2393

  • Rehling, P. (2011), Tinkering with nature. Nat. Rev. Mol. Cell Biol. 12, (7), 401

  • Mick, D.U., Fox, T.D., Rehling, P. (2011), Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nat. Rev. Mol. Cell Biol. 12, 14-20

  • Lupo, D., Vollmer, C., Deckers, M., Mick, D.U., Tews, I., Sinning, I., Rehling, P. (2011), Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane. Traffic 12, (10), 1457-1466

  • von der Malsburg, K., Müller, J.M., Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J.C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner, N., Chacinska, A., van der Laan, M. (2011), Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev. Cell. 21, (4), 694-707

  • Schulz, C., Lytovchenko, O., Melin, J., Chacinska, A., Guiard, B., Neumann, P., Ficner, R., Jahn, O., Schmidt, B., Rehling, P. (2011), Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex. J. Cell. Biol. 195, 643-656

  • Gebert, N., Gebert, M., Oeljeklaus, S., von der Malsburg, K., Stroud, D.A., Kulawiak, B., Wirth, C., Zahedi, R.P., Dolezal, P., Wiese, S., Simon, O., Schulze-Specking, A., Truscott, K.N., Sickmann, A., Rehling, P., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N. (2011), Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane. Mol. Cell 44, (5), 811-818

2010

  • Van der Laan, M., Hutu, D.P., Rehling, P. (2010), On the mechanism of preprotein import by the mitochondrial presequence translocase. Biochim. Biophys. Acta 1803, (6), 732-739

  • Chacinska, A., van der Laan, M., Mehnert, C.S., Guiard, B., Mick, D.U., Hutu, D.P., Truscott, K.N., Wiedemann, N., Meisinger, C., Pfanner, N., and Rehling, P. (2010), Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol. Cell. Biol. 30, (1), 307-318

  • Bauerschmitt, H., Mick, D.U., Deckers, M., Vollmer, C., Funes, S., Kehrein, K., Ott, M., Rehling, P., and Herrmann, J.M. (2010), Ribosome Binding Proteins Mdm38 and Mba1 Display Overlapping Functions for Regulation of Mitochondrial Translation. Mol. Biol. Cell 21, (12), 1937-1944

  • Rehling, P., Rospert, S. (2010), Molecular chaperones and intracellular protein transport. Biochim. Biophys. Acta 1803, (6), 639-640

  • Bohnert, M., Rehling, P., Guiard, B., Herman, J.M., Pfanner, N., van der Laan, M. (2010), Cooperation of stop-transfer and conservative sorting mechanisms in mitochondrial protein transport. Curr. Biol. 20, 1227-1232

  • Mick, D.U., Vukotic, M., Piechura, H., Meyer, H.E., Warscheid, B., Deckers, M., Rehling, P. (2010), Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria. J. Cell Biol. 191, (1), 141-154

2009

  • Odorizzi, G. and Rehling, P. (2009), Membranes and organelles. Curr. Opin. Cell Biol. 21, 481-483

  • Wagner, K., Mick, D.U., and Rehling, P. (2009), Protein transport machineries for precursor translocation across the inner mitochondrial membrane. Biochim. Biophys.Acta. 1793, 52-59

  • Wagner, K., Rehling, P., Szklarz, L.K., Taylor, R.D., Pfanner, N., and van der Laan, M. (2009), Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization. J. Mol. Biol. 392, (4), 855-861

  • Gebert, N., Joshi, A.S., Kutik, S., Becker, T., McKenzie, M., Guan, X.L., Mooga, V.P., Stroud, D.A., Kulkarni, G., Wenk, M.R., Rehling, P., Meisinger, C., Ryan, M.T., Wiedemann, N., Greenberg, M.L., Pfanner, N. (2009), Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr. Biol. 19, (24), 2133-2139

2008

  • Kutik, S., Rissler, M., Guan, X.L., Guiard, B., Shui, G., Gebert, N., Heacock, P.N., Rehling, P., Dowhan, W., Wenk, M.R., Pfanner, N. and Wiedemann, N. (2008), The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J. Cell Biol. 183, 1213-1221

  • Gebert, N., Chacinska, A., Wagner, K., Guiard, B., Koehler, C.M., Rehling, P., Pfanner, N., and Wiedemann, N. (2008), Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep. 9, 548-554

  • Stuart, R. A. and Rehling, P. (2008), Mitochondrial biogenesis: is an old dog still teaching us new tricks?. EMBO Rep. 9, 33-38

  • Hutu, D. P., Guiard, B., Chacinska, A., Becker, D., Pfanner, N., Rehling, P., and Van der Laan, M. (2008), Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase. Mol. Biol. Cell 19, 2642-2649

  • Wagner, K., Gebert, N., Guiard, B., Brandner, K., Truscott, K.N., Wiedemann, N., Pfanner, N., and Rehling, P. (2008), The Assembly Pathway of the Mitochondrial Carrier Translocase Involves four Preprotein Translocases. Mol. Cell. Biol. 28, 4251-4260

2007

  • Reinders, J., Wagner, K., Zahedi, R.P., Stojanovski, D., Eyrich, B., Van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., and Meisinger, C. (2007), Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol. Cell. Proteomics 6, 1896-1906

  • Mick, D. U., Wagner, K., Van der Laan, M., Frazier, A. E., Perschil, I., Pawlas, M., Meyer, H.E., Warscheid, B., and Rehling, P. (2007), Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly. EMBO J. 26, 4347-4358

  • Van der Laan, M., Meinecke, M., Dudek, J., Hutu, D. P., Lind, M., Perschil, I., Guiard, B., Wagner, R., Pfanner, N., and Rehling, P. (2007), Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat. Cell. Biol. 9, 1152-1159

  • Wiedemann N., van der Laan M., Hutu D.P., Rehling P., and Pfanner N. (2007), Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain. J. Cell. Biol. 179, (6), 1115-1122

2006

  • Meinecke, M., Wagner, R., Kovermann, P., Guiard, B., Mick, D.U., Hutu, D.P., Voos, W., Truscott, K.N., Chacinska, A., Pfanner, N., and Rehling, P. (2006), Tim50 Maintains the Permeability Barrier of the Mitochondrial Inner Membrane. Science 312, 1523-1526

  • Frazier, A.E., Taylor, R., Mick, D.U., Warscheid, B., Stoepel, N., Meyer, H.E., Ryan, M.T., Guiard B., and Rehling, P. (2006), Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J. Cell Biol. 172, 553-564

  • Van der Laan, M., Wiedemann, N., Mick, D.U., Guiard, B., Rehling, P., and Pfanner, N. (2006), A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria. Curr. Biol. 16, 2271-2276

  • van der Laan, M., Rissler, M., and Rehling, P. (2006), Presequence translocase of the inner mitochondrial membrane - an intricate and highly dynamic molecular machine. FEMS Yeast Res. 6, 849-861

  • Albrecht, R., Rehling, P., Chacinska, A., Brix, J., Cadamuro, S.A., Volkmer, R., Guiard, B., Pfanner, N. and Zeth, K. (2006), The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. EMBO Rep. 7, 1233-1238

  • Wiedemann, N., Pfanner, N., and Rehling, P. (2006), Import of precursor proteins into isolated yeast mitochondria. Methods Mol. Biol. 313, 373-384

2005

  • Van der Laan, M., Chacinska, A., Lind, M., Perschil, I., Sickmann, A., Meyer, H.E., Guiard B., Meisinger, C., Pfanner, N., and Rehling, P. (2005), Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol. Cell. Biol. 25, 7449-7458

  • Brandner, K., Mick, D.U., Frazier, A.E., Taylor, R.D., Meisinger, C., and Rehling, P. (2005), Taz1, an Outer Mitochondrial Membrane Protein, Affects Stability and Assembly of Inner Membrane Protein Complexes - Implications for Barth Syndrome. Mol. Biol. Cell. 16, 5202-5214.

  • Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling P. (2005), Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-829

  • Brandner, K., Rehling, P., and Truscott, K.N. (2005), The carboxy-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase. J. Biol. Chem. 280, 6215-6221

2004

  • Frazier, A.E., Dudek, J., Guiard, B., Voos, W., Li, Y., Lind, M., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Bilanchone, V., Cumsky, M.G., Truscott, K.N., Pfanner, N., and Rehling, P. (2004), Pam16 plays an essential role in the presequence translocase-associated protein import motor of mitochondria. Nature Struct. Mol. Biol. 11, 226-233

  • Rehling, P., Brandner, K., and Pfanner, N. (2004), Mitochondrial import and the twin-pore translocase. Nature Rev. Mol. Cell Biol. 5, 519-530

  • Li, Y., Dudek, J., Guiard, B., Pfanner, N., Rehling, P., and Voos, W. (2004), The presequence translocase-associated protein import motor of mitochondria. J. Biol. Chem. 11, 38047-38054

  • Chacinska, A., and Rehling, P. (2004), Moving proteins across and in outer and inner membranes of mitochondria. Biochem. Soc. Trans. 32, 774-776

2003

  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., and Meisinger, C. (2003), The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. USA. 100, 13207-13212

  • Truscott, K.N., Voos, W., Frazier, A., Lind, M., Li, Y., Geissler, A., Dudek, J., Müller, H., Sickmann, A., Meyer, H.E., Meisinger, C., Guiard, B., Rehling, P., and Pfanner, N. (2003), A J-protein is an essential subunit of the presequence translocase associated import motor of mitochondria. J. Cell Biol. 163, 707-713

  • Rehling, P., Model, K., Brandner, K., Kovermann, P., Sickmann, A., Meyer, H.E., Kühlbrandt, W., Wagner, R., Truscott, K.N., and Pfanner, N. (2003), Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299, 1747-1751

  • Frazier, A.E., Chacinska, A., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling, P. (2003), Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. Mol. Cell. Biol. 23, 7818-7828

  • Rehling, P., Pfanner, N., and Meisinger, C. (2003), Insertion of Hydrophobic Membrane Proteins into the Mitochondrial Inner Membrane – A Guided Tour. J. Mol. Biol. 326, 639-657

  • Chacinska, A., Rehling, P., Guiard, B., Frazier A.E., Schulze-Specking, A., Pfanner, N., Voos, W., and Meisinger, C. (2003), Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J. 22, 5370-5381

  • Agne, B., Meindl, N.M., Niederhoff, K., Einwächter, H., Rehling, P., Sickmann, A., Meyer, H.E., Girzalsky, W., and Kunau, W.-H. (2003), Pex8p: An intraperoxisomal organizer of two core complexes of the peroxisomal import machinery. Mol. Cell 11, 635-646