Publications

Kilisch M, Lytovchenko O, Arakel EC, Bertinetti D, Schwappach B. (2016) A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1. J Cell Sci. 129:831-42.

Pfaff J, Rivera Monroy J, Jamieson C, Rajanala K, Vilardi F, Schwappach B*, and Kehlenbach RH*. (2016, *co-corresponding) Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane. J Cell Sci. 129:502-16.

Voth, W., Schick, M., Gates, S., Li, S., Vilardi, F., Gostimskaya, I., Southworth, D.R., Schwappach, B.*, and Jakob, U.* (2014, *co-corresponding) The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Molecular Cell 56: 116-127.

Arakel, E.C., Brandenburg S., Zhang H., Lin Y.W., Kohl T, Schrul B., Nichols C.G., Lehnart S.E., Schwappach, B. (2014) Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes. J. Cell Sci. 127: 2106-2119.

Vilardi, F., Stephan, M., Clancy, A., Janshoff, A., and Schwappach, B. (2014) WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane. PLoS One 9: e85033.

Leznicki, P., Roebuck, Q.P., Wunderley, L., Clancy, A., Krysztofinska, E.M., Isaacson, R.L., Warwicker, J., Schwappach, B., and High, S. (2013). The association of BAG6 with SGTA and tail-anchored proteins. PLoS One 8: e59590.

Powis, K., Schrul, B., Tienson, H., Gostimskaya, I., Breker, M., High, S., Schuldiner, M., Jakob, U., and Schwappach, B. (2013) Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked. J. Cell Sci. 126: 473-482.

Wolf, W., Kilic, A., Schrul, B., Lorenz, H., Schwappach, B. and Seedorf, M. (2012) Yeast Ist2 recruits the endoplasmic reticulum to the plasma membrane and creates a ribosome-free membrane microcompartment. PLOSone 7, e39703.

Smith, A.J., Daut, J., and Schwappach, B. (2011) Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport. Physiology 26, 181-191.

Simpson, P.J., Schwappach, B., Dohlmann H.G., Isaacson, R.L. (2010). Structures of Get3, Get4 and Get5 provide new models for TA membrane protein targeting. Structure 18: 897-902.

Braun, N.A., Morgan, B., Dick, T.P., and Schwappach, B. (2010) The yeast CLC protein counteracts vesicular acidification during iron starvation. J. Cell Sci. 123: 2342-2350.

Leznicki, P., Clancy, A., Schwappach, B., and High. S. (2010). Bat3 promotes the membrane integration of tail-anchored proteins. J. Cell Sci. 123: 2170-2178.

Rabu, C., Schmid, V., Schwappach, B., and High, S. (2009) Biogenesis of tail-anchored proteins: the beginning for the end? J. Cell Sci. 122, 3605-3612.

Jonikas, M.C., Collins, S.R., Denic, V., Oh, E., Quan, E.M., Schmid, V., Weibezahn, J., Schwappach, B., Walter, P., Weissman, J.S., Schuldiner, M. (2009). Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323: 1693-1697.

Zuzarte, M., Heusser, K., Renigunta, V., Schlichthörl, G., Rinne, S., Wischmeyer, E., Daut, J.*, Schwappach, B.*, and Preisig-Müller, R.* (2009, *co-corresponding). Intracellular traffic of the K+ channels TASK-1 and TASK-3: Role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. J. Physiol. 587: 929-952.

Schuldiner, M., Metz, J., Schmid, V., Denic, V., Rakwalska, M., Schmitt, H.D, Schwappach, B.*, and Weissman, J.S.* (2008, *co-corresponding). The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Cell 134: 634-645.

Spasic, M., Favaloro, V., Schwappach, B. and Dobberstein B. (2008). Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. J. Cell Sci. 121: 1832-1840.

Schwappach, B. (2008). An overview of trafficking and assembly of neurotransmitter receptors and ion channels. Mol. Membr. Biol. 25: 270-278.

Michelsen, K., Schmid, V., Metz, J., Heusser, K., Liebel, U., Schwede, T., Spang, A., and Schwappach, B. (2007). Novel cargo-binding site in the beta and delta subunits of coatomer. J. Cell Biol. 179: 209-217.

Mrowiec, T. and Schwappach, B. (2006). 14-3-3 proteins in membrane protein transport. Biological Chemistry 387: 1227-1236.

Heusser, K., Yuan, H., Neagoe, I., Tarasov, A., Ashcroft, F., and Schwappach, B. (2006). Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface expression of ATP-sensitive potassium channels. J. Cell Sci. 119: 4353-4363.

Michelsen, K., Mrowiec, T., Duderstadt, K.E., Frey, S., Minor, D.L., Mayer M.P., and Schwappach, B. (2006). A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Traffic 7: 903-916.

Varadi, A., Grant, A., McCormack, M., Nicolson, T., Magistri, M., Mitchell, K.J., Halestrap, A. P., Yuan, H.,  Schwappach, B., and Rutter G.A. (2006). Intracellular ATP-sensitive K+ channels in mouse beta cells: against a role in organelle cation homeostasis. Diabetologia 49: 1567-1577.

Metz, J., Wächter, A., Schmidt, B., Bujnicki, J.M., and Schwappach, B. (2006). The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol. J. Biol. Chem. 281: 410-417.

Renigunta, V., Yuan, H., Zuzarte, M., Rinne, S., Koch, A., Wischmeyer, E., Schlichthörl, G., Gao, Y., Karschin, A., Jacob, R., Schwappach, B., Daut, J., and Preisig-Müller, R. (2006). The retention factor p11 confers an ER-localisation signals to the potassium channel TASK-1. Traffic 7: 161-168.

Michelsen, K., Yuan, H., and Schwappach, B. (2005). Hide and run: Arginine-based ER-sorting motifs in the assembly of heteromultimeric membrane proteins. EMBO Reports 6: 717-722.

Jüschke, C., Wachter, A., Schwappach, B., and Seedorf, M. (2005). SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane. J. Cell Biol. 169: 613-622.

Stegmayer, C., Kehlenbach, A., Tournaviti, S., Wegehingel, S., Zehe, C., Denny, P., Smith, D.F., Schwappach, B., and Nickel, W. (2005). Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant. J. Cell Sci. 118: 517-527.

Wächter, A. and Schwappach, B. (2005). The yeast chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop. FEBS Letters 579: 1149-1153.

Heusser, K. and Schwappach, B. (2005). Potassium channel trafficking. Cur. Op. Neurobiol. 15: 364-369.

Backhaus, R., Zehe, C., Wegehingel, S., Kehlenbach, A., Schwappach, B., Nickel, W. (2004). Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding. J. Cell Sci. 117: 1727-1736.

Neagoe, I. and Schwappach, B. (2004). Pas de Deux in groups of four - The biogenesis of KATP channels. J. Mol. Cell. Card. 38: 887-894.

Yuan, H., Michelsen K., and Schwappach, B. (2003). 14-3-3 dimers probe the assembly status of multimeric membrane proteins. Curr. Biol. 13: 638-646.

Benharouga, M., Sharma, M., So, J., Haardt, M., Drzymala, L., Popov, M., Schwappach, B., Grinstein, S., Du, K., Lukacs, G.L. (2003). The role of the C-terminus and Na/H+ exchanger regulatory factor (NHERF) in the functional expression of CFTR in non-polarized cells and epithelia. J. Biol. Chem. 278: 22079-22089.