Publications

orcid.org/0000-0002-1720-3440

• Strenzke N., Chakrabarti R., Al-Moyed H., Müller A., Hoch G., Pangrsic T., Yamanbaeva G., Lenz C., Pan KT., Auge E., Geiss-Friedlander R., Urlaub H., Brose N., Wichmann C. and Reisinger E. (2016) Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. EMBO DOI: 10.15252/embj.201694564

** this publication was honoured in the 14th round of GöVIP (Very Important Publications) by the Research Commission of the UMG www.med.uni-goettingen.de/de/content/ueberuns/20315.html

• Justa-Schuch, D., Silva-Garcia, M., Pilla, E., Engelke, M., Kilisch, M., Lenz, C., Möller, U., Nakamura, F., Urlaub, H. and Geiss-Friedlander, R. (2016) DPP9 is a novel component of the N-end rule pathway targeting the Tyrosine Kinase Syk. eLife DOI: 10.7554/eLife.16370.

** this publication was honoured in the 13th round of GöVIP (Very Important Publications) by the Research Commission of the UMG www.med.uni-goettingen.de/de/content/ueberuns/20315.html

• Zhang, H; Maqsudi, S., Rainczuk, A., Duffield, N; Lawrence, J., Keane, FM., Justa-Schuch, D., Geiss-Friedlander, R., Gorrell, MD., Stephens, AN. (2015) Identification of Novel Dipeptidyl Peptidase 9 Substrates by 2D DIGE. FEBS doi: 10.1111/febs.13371.

• Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kügler, S., Lockhart, L.F., Schwalbe, M., Krumova, P., Oliveira, L.M.A., Bähr, M., Möbius, W., Levin, J., Giese, A., Kruse, N., Mollenhauer, B., Geiss-Friedlander, R., Ludolph, A.C., Freischmidt, A., Feiler, M.S., Danzer, K.M., Zweckstetter, M., Jovin, T.M., Simons, M., Weishaupt, J.H. and Schneider A. (2015) Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathol doi:10.1007/s00401-015-1408-1 .

• Justa-Schuch, D., Möller, U., and Geiss-Friedlander, R. (2014) The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. Cell. Mol. Life Sci. 71(18): 3611-3626.

• Pilla, E., Kilisch, M., Lenz, C., Urlaub, H., and Geiss-Friedlander, R. (2013) The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. J Biol Chem 288: 32787–32796.

• Pilla, E., Moller, U., Sauer, G., Mattiroli, F., Melchior, F., and Geiss Friedlander, R. (2012) A novel SUMO1-specific interacting motif in Dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J Biol Chem 287: 44320–44329.

• Geiss-Friedlander R*, Parmentier N, Moller U, Urlaub H, Van den Eynde BJ, Melchior F* (2009) The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. J Biol Chem 284: 27211-27219. * corresponding authors.

• Geiss-Friedlander R, Melchior F. (2008) SUMOylation. In Offermanns SR, Walter (ed.), Encyclopedia of Molecular Pharmacology. Springer, Vol. 2, pp. 1163-1167

• Geiss-Friedlander R, Melchior F (2007) Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol 8: 947-956.

• Granot Z, Geiss-Friedlander R, Melamed-Book N, Eimerl S, Timberg R, Weiss AM, Hales KH, Hales DB, Stocco DM, Orly J (2003) Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins. Mol Endocrinol 17: 2461-2476.

• Jarosch E, Geiss-Friedlander R, Meusser B, Walter J, Sommer T (2002) Protein dislocation from the endoplasmic reticulum--pulling out the suspect. Traffic 3: 530-536.

• Granot Z, Silverman E, Friedlander R, Melamed-Book N, Eimerl S, Timberg R, Hales KH, Hales DB, Stocco DM, Orly J (2002) The life cycle of the steroidogenic acute regulatory (StAR) protein: from transcription through proteolysis. Endocr Res 28: 375-386.

• Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2: 379-384.

 

 

PATENT

‘Specific DPP8 and/or DPP9 inhibitors.’ Inventors: Ruth Geiss-Friedlander and Esther Pilla. WO2014068023, US9593148B2. Issued on March 14, 2017.