An open position for a PhD student (f/m) in biochemistry and cell biology
Proteases in cell signalling and cell survival
The aim of the proposed PhD project is to investigate the molecular role of two proteolytic enzymes DPP8 and DPP9 in cell survival and in signalling events. DPP8 and DPP9 are two unique proline-cleaving proteases that are linked to cancer, cell signalling, immunology responses and neonatal survival. By cleaving their substrates at specific sites (limited proteolysis), proteolytic enzymes act as non-reversible post-translational modifiers which effect multiple biological pathways, often by modifying protein interactions. Previously we identified several novel substrates and interacting proteins of DPP8 and DPP9, including Syk, a central tyrosine kinase in B-cell receptor mediated signalling. We showed that DPP9 acts as a molecular switch, which regulates Syk stability by the N-end rule pathway.
Research in this project will focus on the characterization of selected novel DPP8 and DPP9 substrates, to investigate the molecular role of these proteases in cell survival and signalling events. Experimental work in the lab combines biochemical in vitro techniques with cell-based assays using human and mouse cell lines.
We are looking for a motivated and hardworking applicant who is curious and open for new challenges. The applicant should possess a good understanding in biochemistry and experience in cell culture.
We offer an extremely attractive and dynamic working environment with highly interacting groups and excellent research facilities (with English as a spoken language). We provide an optimal supervision of the PhD project, with a structured PhD program. After acceptance, candidates can apply for a PhD program in Molecular Medicine or in the Graduate School GGNB, which is part of the German Excellence Initiative (http://www.uni-goettingen.de/en/sh/56640.html). As part of a Göttingen graduate school he/she will have the opportunity to attend a broad range of training opportunities.
If you are interested, please send your application until 5.10.2017 to firstname.lastname@example.org. Alternatively, applications can be send to: Dr. Ruth Geiss-Friedlander, Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany. A full application should contain the following documents: curriculum vitae, a letter summarizing the motivation to join the group and relevant work experience, as well as scans of your university certificates.
Interested candidates are welcome to apply for internships, Bachelor or Master thesis. These projects are connected to protease function and regulation, protein quality control and modification of proteins by small ubiquitin like protein modifiers (SUMO). Methods in the lab include molecular biology, biochemistry and cell biology