Publications

2017

  • Krueger-Burg, D., Papadopoulos, T., Brose, N. (2017) Organizers of inhibitory synapses come of age. Curr. Opin. Neurobiol., 45: 66-77.

  • Papadopoulos, T., Rhee, H.J., Subramanian, D., Paraskevopoulou, F., Mueller, R., Schultz, C., Brose, N., Rhee, J.-S., Betz, H. (2017) Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses. J. Biol. Chem., 292: 1160-1177.

 

2016

  • Um, J.W, Choii, G., Park, D., Kim, D., Jeon, S., Kang H., Mori, T., Papadopoulos, T., Yoo, T., Lee, Y., Kim, E., Tabuchi, K., Ko, J. (2016) IQ Motif and SEC7 Domain-Containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation. J. Biol. Chem., 291: 10119-10130.

  • Ludolphs, M., Schneeberger, D., Soykan, T., Schäfer, J., Papadopoulos, T., Brose, N., Schindelin, H., Steinem, C. (2016) Specificity of Collybistin-Phosphoinositide Interactions - Impact of the individual protein domains. J. Biol. Chem., 291: 244-254.

 

2015 

  • Papadopoulos, T., Schemm, R., Grubmüller, H., Brose, N. (2015) Lipid binding defects and perturbed synaptogenic activity of a collybistinR290H mutant that causes epilepsy and intellectual disability. J. Biol. Chem., 290: 8256-8270.

 

2014

  • Soykan, T., Schneeberger, D., Tria, G., Buechner, C., Bader, N., Svergun, D., Tessmer, I., Poulopoulos, A., Papadopoulos, T., Varoqueaux, F., Schindelin, H., Brose, N. (2014) A conformational switch in collybistin determines the differentiation of inhibitory postsynapses EMBO J., 33: 2113-2133.

 

2013

  • Mayer, S., Kumar, R., Jaiswal, M., Soykan, T., Ahmadian, M. R., Brose, N., Betz, H., Rhee, J.-S., Papadopoulos, T. (2013) Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc. Natl. Acad. Sci. USA, 110: 20795-20800.

  • Vlachos, A., Reddy-Alla, S., Papadopoulos, T., Deller, T., Betz, H. (2013) Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapses. Cereb. Cortex, 23: 2700-2711.

 

2012

  • Krueger, D. D., Tuffy, L. P., Papadopoulos, T. and Brose, N. (2012) The role of neurexins and neuroligins in the formation, maturation, and fuction of vertebrate synapses. Curr. Opin. Neurobiol., 22: 1-11.

 

2011

  • Papadopoulos, T. and Soykan, T. (2011) The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions. Front. Cell. Neurosci., 5: 11.

  • Jedlicka, P., Hoon, M., Papadopoulos, T., Vlachos, A., Winkels, R., Poulopoulos, A., Betz, H., Deller, T., Brose, N., Varoqueaux, F., Schwarzacher, S. W. (2011) Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb. Cortex, 21: 357-367.

 

2010

  • Ishihara, N., Armsen, W., Papadopoulos, T., Betz, H., Eulenburg, V. (2010) Generation of a mouse line expressing Cre recombinase in glycinergic interneurons. Genesis, 48: 437-445.

  • Eulenburg, V., Retiounskaia, M., Papadopoulos, T., Gomeza, J., Betz, H. (2010) Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice. Glia, 58: 1066-1073.

  • Reddy-Alla, S., Schmitt, B., Birkenfeld, J., Eulenburg, V., Dutertre, S., Böhringer, C., Götz, M., Betz, H., Papadopoulos, T. (2010) PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering. Eur. J. Neurosci., 31: 1173-1184.

 

2009

  • Poulopoulos, A., Aramuni, G., Meyer, G., Soykan, T., Hoon, M., Papadopoulos, T., Zhang, M., Paarmann, I., Fuchs, C., Harvey, K., Jedlicka, P., Schwarzacher S. W., Betz, H., Harvey, R. J., Brose, N., Zhang, W., Varoqueaux, F. (2009) Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin. Neuron, 63: 628-642.

  • Jedlicka, P., Papadopoulos, T., Deller, T., Betz, H., Schwarzacher, S. W. (2009)
    Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo. Mol. Cell. Neurosci., 41: 94-100.

 

2008

  • Papadopoulos, T., Eulenburg, V., Reddy-Alla, S., Mansuy, I. M., Li, Y., Betz, H. (2008) Collybistin is required for both the formation and maintenance of GABAergic postsynapses in the hippocampus.
    Mol. Cell. Neurosci., 39: 161-169.

 

2007

  • Papadopoulos, T., Korte, M., Eulenburg, V., Kubota, H., Retiounskaia, M., Harvey, R. J., Harvey, K., O’Sullivan, G. A., Laube, B., Hülsmann, S., Geiger, J. R., Betz, H. (2007) Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J., 26: 3888-3899.

 

2001

  • Papadopoulos, T., Kelly, J. A., Bauer, K. (2001) Mutational analysis of the thyrotropin-releasing hormone-degrading ectoenzyme. Similarities and differences with other members of the M1 family of aminopeptidases and thermolysin. Biochemistry, 40: 9347-9355.

 

2000

  • Papadopoulos, T., Heuer, H., Bauer, K. (2000) Analysis of the thyrotropin-releasing hormone-degrading ectoenzyme by site-directed mutagenesis of cysteine residues. Cys68 is involved in disulfide-linked dimerization. Eur. J. Biochem., 267: 2617-2623.