Curriculum vitae

  • 1991 – 1993 Diploma work in the lab of Prof. Dr. E.W. Weiler, Ruhr-Universität-Bochum.
  • 1993 – 1996 PhD thesis in the lab of Prof. Dr. Dr. W.-H. Kunau at the Institut für Physiologische Chemie, Ruhr University Bochum.
  • 1996 – 1998 Postdoctoral position in the lab of Prof. Dr. Dr. W.-H. Kunau.
  • 1998 – 2000 Postdoctoral position in the lab of Prof. Dr. S.D. Emr, Howard Hughes Medical Institute and Division of Cellular & Molecular Medicine, University of California San Diego, USA.
  • 2000 – 2004 Assistant professor (Habilitation) at the Institute for Biochemistry and Molecular Biology, University of Freiburg.
  • 2001 – 2006 Group leader in the SFB388 Zelluläre Funktionen dynamischer Proteinwechselwirkungen.
  • 2003 Habilitation for Biochemistry and Molecular Biology at the Medical Faculty, University of Freiburg.
  • since 2007 Head of the Department of Cellular Biochemistry (formerly Biochemistry II) of the University of Göttingen
  • 2010 – Max Planck Institute for Biophysical Chemistry Research Fellow
  • 2015 – Program Director International Max Planck Research School “Molecular Biology”
  • 2016 – Coordinator Collaborative Research Center on “Compartmental Gates and Contact Sites in cells” (SFB1190)

Awards and Honors

  • 2004 Research Award of the University of Freiburg
  • 2005 Young Investigator Award of the GBM and Schering Stiftung
  • 2013 ERC Advanced Grant „Mitochondrial translational regulation coupled to respiratory chain assembly and protein import“ – MITRAC”
  • 2016 Copernicus Award of the DFG and FNP together with Prof. Dr. A. Chacinska

ERC-MITRAC

Mitochondrial translational regulation coupled to respiratory chain assembly and protein import

Mitochondrial respiratory chain complexes assemble from nuclear- and mitochondria-encoded subunits in the inner membrane. To protect cells from accumulating unassembled subunits in the membrane, ROS generation, or damage of mitochondrial integrity, regulatory mechanisms to balance and control the fidelity of the assembly process have evolved, encorporating a retention system enabling the preservation of a select few founding complexes for on-demand assembly. In yeast mitochondria, a feedback mechanism has been identified for the cytochrome oxidase in which assembly-intermediates specifically inactivate translation of the core subunit Cox1. It is controversially debated if similar translation regulating mechanisms exist in human mitochondria. However, our recent findings show that in human mitochondria assembly intermediates of respiratory chain complexes affect translation, nevertheless the underlying sensing and signalling mechanisms as well as the protein components appear to be more complex than in yeast. We aim to understand how this regulatory cycle is established; how does a distinct assembly intermediate of cytochrome oxidase signal the translation system, and how the influx of imported subunits contributes to this process. These goals are conceptually deeply rooted in a comprehensive understanding of the membrane protein complex assembly process and the factors that promote its progression. These objectives are of key importance for understanding the molecular pathology of mitochondrial encephalomyopathies that are frequently due to respiratory chain assembly and quality control malfunction. The aim of our analyses is to provide insight as to how translation can be coupled to the assembly of a membrane protein complex comprised of subunits of dual genetic origin and to decipher mitochondrial translational regulation coupling to the influx of imported nuclear encoded subunits.

Publications (since 2003)

2020
Valpadashi A., Callegari S., Linden A., Neumann P., Ficner R., Urlaub H., Deckers M., Rehling P. (2020) Defining the architecture of the human TIM22 complex by chemical crosslinking. FEBS Lett , .

Stephan T., Brüser C., Deckers M., Steyer A., Balzarotti F., Barbot M., Behr T., Heim G., Hübner W., Ilgen P., Lange F., Pacheu-Grau D., Pape J., Stoldt S., Huser T., Hell S., Möbius W., Rehling P., Riedel D., Jakobs S. (2020) MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation. EMBO J 39, e104105.

Linden A., Deckers M., Parfentev I., Pflanz R., Homberg B., Neumann P., Ficner R., Rehling P., Urlaub H. (2020) A Cross-linking Mass Spectrometry Approach Defines Protein Interactions in Yeast Mitochondria. Mol Cell Proteomics 19, 1161-1178.

Gomkale R., Cruz-Zaragoza L., Suppanz I., Guiard B., Montoya J., Callegari S., Pacheu-Grau D., Warscheid B., Rehling P. (2020) Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos. Curr Biol 30, 1119-1127.e5.

Callegari S., Cruz-Zaragoza L., Rehling P. (2020) From TOM to the TIM23 complex – handing over of a precursor. Biol Chem 401, 709-721.

Pacheu-Grau D., Wasilewski M., Oeljeklaus S., Gibhardt C., Aich A., Chudenkova M., Dennerlein S., Deckers M., Bogeski I., Warscheid B., Chacinska A., Rehling P. (2020) COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria. J Mol Biol 432, 2067-2079.

Wang C., Richter-Dennerlein R., Pacheu-Grau D., Liu F., Zhu Y., Dennerlein S., Rehling P. (2020) MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep 21, e48833.

2019
Zhang X., Gibhardt C., Will T., Stanisz H., Körbel C., Mitkovski M., Stejerean I., Cappello S., Pacheu-Grau D., Dudek J., Tahbaz N., Mina L., Simmen T., Laschke M., Menger M., Schön M., Helms V., Niemeyer B., Rehling P., Vultur A., Bogeski I. (2019) Redox signals at the ER-mitochondria interface control melanoma progression. EMBO J 38, e100871.

Callegari S., Rehling P. (2019) Guarding the gate for mitochondrial entry. Nature 569, 635-637.

Can K., Menzfeld C., Rinne L., Rehling P., Kügler S., Golubiani G., Dudek J., Müller M. (2019) Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O 2 Consumption and ROS Release. Front Physiol 10, 479.

Callegari S., Müller T., Schulz C., Lenz C., Jans D., Wissel M., Opazo F., Rizzoli S., Jakobs S., Urlaub H., Rehling P., Deckers M. (2019) A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria. J Mol Biol 431, 2835-2851.

Mohanraj K., Wasilewski M., Benincá C., Cysewski D., Poznanski J., Sakowska P., Bugajska Z., Deckers M., Dennerlein S., Fernandez-Vizarra E., Rehling P., Dadlez M., Zeviani M., Chacinska A. (2019) Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7. EMBO Mol Med 11, .

Dudek J., Hartmann M., Rehling P. (2019) The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease. Biochim Biophys Acta Mol Basis Dis 1865, 810-821.

Nanadikar M., Vergel Leon A., Borowik S., Hillemann A., Zieseniss A., Belousov V., Bogeski I., Rehling P., Dudek J., Katschinski D. (2019) O2 affects mitochondrial functionality ex vivo. Redox Biol 22, 101152.

Antunes D., Chowdhury A., Aich A., Saladi S., Harpaz N., Stahl M., Schuldiner M., Herrmann J., Rehling P., Rapaport D. (2019) Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1. J Mol Med (Berl) 97, 269-279.

Richter F., Dennerlein S., Nikolov M., Jans D., Naumenko N., Aich A., MacVicar T., Linden A., Jakobs S., Urlaub H., Langer T., Rehling P. (2019) ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. J Cell Biol 218, 598-614.

2018
Saal K., Richter F., Rehling P., Rizzoli S. (2018) Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry. ACS Nano 12, 12247-12254.

Pacheu-Grau D., Callegari S., Emperador S., Thompson K., Aich A., Topol S., Spencer E., McFarland R., Ruiz-Pesini E., Torkamani A., Taylor R., Montoya J., Rehling P. (2018) Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy. Hum Mol Genet 27, 4135-4144.

Mandad S., Rahman R., Centeno T., Vidal R., Wildhagen H., Rammner B., Keihani S., Opazo F., Urban I., Ischebeck T., Kirli K., Benito E., Fischer A., Yousefi R., Dennerlein S., Rehling P., Feussner I., Urlaub H., Bonn S., Rizzoli S., Fornasiero E. (2018) The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Sci Rep 8, 16913.

Chowdhury A., Aich A., Jain G., Wozny K., Lüchtenborg C., Hartmann M., Bernhard O., Balleiniger M., Alfar E., Zieseniss A., Toischer K., Guan K., Rizzoli S., Brügger B., Fischer A., Katschinski D., Rehling P., Dudek J. (2018) Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep 25, 561-570.e6.

Fornasiero E., Mandad S., Wildhagen H., Alevra M., Rammner B., Keihani S., Opazo F., Urban I., Ischebeck T., Sakib M., Fard M., Kirli K., Centeno T., Vidal R., Rahman R., Benito E., Fischer A., Dennerlein S., Rehling P., Feussner I., Bonn S., Simons M., Urlaub H., Rizzoli S. (2018) Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nat Commun 9, 4230.

Schendzielorz A., Bragoszewski P., Naumenko N., Gomkale R., Schulz C., Guiard B., Chacinska A., Rehling P. (2018) Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane. Nat Commun 9, 4028.

Aich A., Wang C., Chowdhury A., Ronsör C., Pacheu-Grau D., Richter-Dennerlein R., Dennerlein S., Rehling P. (2018) COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Elife 7, .

Lorenzi I., Oeljeklaus S., Aich A., Ronsör C., Callegari S., Dudek J., Warscheid B., Dennerlein S., Rehling P. (2018) The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Biochim Biophys Acta Mol Cell Res 1865, 323-333.

Richter K., Revelo N., Seitz K., Helm M., Sarkar D., Saleeb R., D’Este E., Eberle J., Wagner E., Vogl C., Lazaro D., Richter F., Coy-Vergara J., Coceano G., Boyden E., Duncan R., Hell S., Lauterbach M., Lehnart S., Moser T., Outeiro T., Rehling P., Schwappach B., Testa I., Zapiec B., Rizzoli S. (2018) Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy. EMBO J 37, 139-159.

2017
Naumenko N., Morgenstern M., Rucktäschel R., Warscheid B., Rehling P. (2017) INA complex liaises the F1Fo-ATP synthase membrane motor modules. Nat Commun 8, 1237.

Denkert N., Schendzielorz A., Barbot M., Versemann L., Richter F., Rehling P., Meinecke M. (2017) Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import. Elife 6, .

Dennerlein S., Wang C., Rehling P. (2017) Plasticity of Mitochondrial Translation. Trends Cell Biol 27, 712-721.

Schendzielorz A., Schulz C., Lytovchenko O., Clancy A., Guiard B., Ieva R., van der Laan M., Rehling P. (2017) Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation. J Cell Biol 216, 83-92.

Callegari S., Oeljeklaus S., Warscheid B., Dennerlein S., Thumm M., Rehling P., Dudek J. (2017) Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects. Autophagy 13, 201-211.

Guentsch A., Beneke A., Swain L., Farhat K., Nagarajan S., Wielockx B., Raithatha K., Dudek J., Rehling P., Zieseniss A., Jatho A., Chong M., Santos C., Shah A., Katschinski D. (2017) PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages. Mol Cell Biol 37, .

2016
Callegari S., Richter F., Chojnacka K., Jans D., Lorenzi I., Pacheu-Grau D., Jakobs S., Lenz C., Urlaub H., Dudek J., Chacinska A., Rehling P. (2016) TIM29 is a subunit of the human carrier translocase required for protein transport. FEBS Lett 590, 4147-4158.

Richter-Dennerlein R., Oeljeklaus S., Lorenzi I., Ronsör C., Bareth B., Schendzielorz A., Wang C., Warscheid B., Rehling P., Dennerlein S. (2016) Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell 167, 471-483.e10.

Lorenzi I., Oeljeklaus S., Ronsör C., Bareth B., Warscheid B., Rehling P., Dennerlein S. (2016) Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates. Mol Cell Biol 36, 2782-2793.

Haag S., Sloan K., Ranjan N., Warda A., Kretschmer J., Blessing C., Hübner B., Seikowski J., Dennerlein S., Rehling P., Rodnina M., Höbartner C., Bohnsack M. (2016) NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. EMBO J 35, 2104-2119.

Levchenko M., Wuttke J., Römpler K., Schmidt B., Neifer K., Juris L., Wissel M., Rehling P., Deckers M. (2016) Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. Biochim Biophys Acta 1863, 1624-32.

Bareth B., Nikolov M., Lorenzi I., Hildenbeutel M., Mick D., Helbig C., Urlaub H., Ott M., Rehling P., Dennerlein S. (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell 27, 1570-80.

Heininger A., Hackert P., Andreou A., Boon K., Memet I., Prior M., Clancy A., Schmidt B., Urlaub H., Schleiff E., Sloan K., Deckers M., Lührmann R., Enderlein J., Klostermeier D., Rehling P., Bohnsack M. (2016) Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biol 13, 320-30.

Dudek J., Cheng I., Chowdhury A., Wozny K., Balleininger M., Reinhold R., Grunau S., Callegari S., Toischer K., Wanders R., Hasenfuß G., Brügger B., Guan K., Rehling P. (2016) Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med 8, 139-54.

2015
Richter-Dennerlein R., Dennerlein S., Rehling P. (2015) Integrating mitochondrial translation into the cellular context. Nat Rev Mol Cell Biol 16, 586-92.

Dennerlein S., Oeljeklaus S., Jans D., Hellwig C., Bareth B., Jakobs S., Deckers M., Warscheid B., Rehling P. (2015) MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly. Cell Rep 12, 1644-55.

Pacheu-Grau D., Bareth B., Dudek J., Juris L., Vögtle F., Wissel M., Leary S., Dennerlein S., Rehling P., Deckers M. (2015) Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. Cell Metab 21, 823-33.

Melin J., Kilisch M., Neumann P., Lytovchenko O., Gomkale R., Schendzielorz A., Schmidt B., Liepold T., Ficner R., Jahn O., Rehling P., Schulz C. (2015) A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria. Biochim Biophys Acta 1853, 1850-9.

Dennerlein S., Rehling P. (2015) Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance. J Cell Sci 128, 833-7.

Schulz C., Schendzielorz A., Rehling P. (2015) Unlocking the presequence import pathway. Trends Cell Biol 25, 265-75.

2014
Schulz C., Rehling P. (2014) Cell biology. Powering the cell cycle. Science 346, 1059-60.

Gornicka A., Bragoszewski P., Chroscicki P., Wenz L., Schulz C., Rehling P., Chacinska A. (2014) A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Mol Biol Cell 25, 3999-4009.

Schulz C., Rehling P. (2014) Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation. Nat Commun 5, 4349.

Melin J., Schulz C., Wrobel L., Bernhard O., Chacinska A., Jahn O., Schmidt B., Rehling P. (2014) Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix. Mol Cell Biol 34, 3473-85.

Lytovchenko O., Naumenko N., Oeljeklaus S., Schmidt B., von der Malsburg K., Deckers M., Warscheid B., van der Laan M., Rehling P. (2014) The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase. EMBO J 33, 1624-38.

Pfanner N., van der Laan M., Amati P., Capaldi R., Caudy A., Chacinska A., Darshi M., Deckers M., Hoppins S., Icho T., Jakobs S., Ji J., Kozjak-Pavlovic V., Meisinger C., Odgren P., Park S., Rehling P., Reichert A., Sheikh M., Taylor S., Tsuchida N., van der Bliek A., van der Klei I., Weissman J., Westermann B., Zha J., Neupert W., Nunnari J. (2014) Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol 204, 1083-6.

2013
Bareth B., Dennerlein S., Mick D., Nikolov M., Urlaub H., Rehling P. (2013) The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Mol Cell Biol 33, 4128-37.

Welter E., Montino M., Reinhold R., Schlotterhose P., Krick R., Dudek J., Rehling P., Thumm M. (2013) Uth1 is a mitochondrial inner membrane protein dispensable for post-log-phase and rapamycin-induced mitophagy. FEBS J 280, 4970-82.

Dudek J., Cheng I., Balleininger M., Vaz F., Streckfuss-Bömeke K., Hübscher D., Vukotic M., Wanders R., Rehling P., Guan K. (2013) Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome. Stem Cell Res 11, 806-19.

Jans D., Wurm C., Riedel D., Wenzel D., Stagge F., Deckers M., Rehling P., Jakobs S. (2013) STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria. Proc Natl Acad Sci U S A 110, 8936-41.

Lytovchenko O., Melin J., Schulz C., Kilisch M., Hutu D., Rehling P. (2013) Signal recognition initiates reorganization of the presequence translocase during protein import. EMBO J 32, 886-98.

Dudek J., Rehling P., van der Laan M. (2013) Mitochondrial protein import: common principles and physiological networks. Biochim Biophys Acta 1833, 274-85.

2012
Mick D., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E., Warscheid B., Rehling P. (2012) MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell 151, 1528-41.

Reinhold R., Krüger V., Meinecke M., Schulz C., Schmidt B., Grunau S., Guiard B., Wiedemann N., van der Laan M., Wagner R., Rehling P., Dudek J. (2012) The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Mol Cell Biol 32, 5009-21.

Keil M., Bareth B., Woellhaf M., Peleh V., Prestele M., Rehling P., Herrmann J. (2012) Oxa1-ribosome complexes coordinate the assembly of cytochrome C oxidase in mitochondria. J Biol Chem 287, 34484-93.

Krüger V., Deckers M., Hildenbeutel M., van der Laan M., Hellmers M., Dreker C., Preuss M., Herrmann J., Rehling P., Wagner R., Meinecke M. (2012) The mitochondrial oxidase assembly protein1 (Oxa1) insertase forms a membrane pore in lipid bilayers. J Biol Chem 287, 33314-26.

Vukotic M., Oeljeklaus S., Wiese S., Vögtle F., Meisinger C., Meyer H., Zieseniss A., Katschinski D., Jans D., Jakobs S., Warscheid B., Rehling P., Deckers M. (2012) Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. Cell Metab 15, 336-47.

2011
Gebert N., Gebert M., Oeljeklaus S., von der Malsburg K., Stroud D., Kulawiak B., Wirth C., Zahedi R., Dolezal P., Wiese S., Simon O., Schulze-Specking A., Truscott K., Sickmann A., Rehling P., Guiard B., Hunte C., Warscheid B., van der Laan M., Pfanner N., Wiedemann N. (2011) Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell 44, 811-8.

Schulz C., Lytovchenko O., Melin J., Chacinska A., Guiard B., Neumann P., Ficner R., Jahn O., Schmidt B., Rehling P. (2011) Tim50’s presequence receptor domain is essential for signal driven transport across the TIM23 complex. J Cell Biol 195, 643-56.

von der Malsburg K., Müller J., Bohnert M., Oeljeklaus S., Kwiatkowska P., Becker T., Loniewska-Lwowska A., Wiese S., Rao S., Milenkovic D., Hutu D., Zerbes R., Schulze-Specking A., Meyer H., Martinou J., Rospert S., Rehling P., Meisinger C., Veenhuis M., Warscheid B., van der Klei I., Pfanner N., Chacinska A., van der Laan M. (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell 21, 694-707.

Lupo D., Vollmer C., Deckers M., Mick D., Tews I., Sinning I., Rehling P. (2011) Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane. Traffic 12, 1457-66.

Rehling P. (2011) Tinkering with nature. Nat Rev Mol Cell Biol 12, 401.

Reinhold R., Bareth B., Balleininger M., Wissel M., Rehling P., Mick D. (2011) Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Hum Mol Genet 20, 2379-93.

Mick D., Fox T., Rehling P. (2011) Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nat Rev Mol Cell Biol 12, 14-20.

2010
Mick D., Vukotic M., Piechura H., Meyer H., Warscheid B., Deckers M., Rehling P. (2010) Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria. J Cell Biol 191, 141-54.

Bohnert M., Rehling P., Guiard B., Herrmann J., Pfanner N., van der Laan M. (2010) Cooperation of stop-transfer and conservative sorting mechanisms in mitochondrial protein transport. Curr Biol 20, 1227-32.

Rehling P., Rospert S. (2010) Molecular chaperones and intracellular protein transport. Biochim Biophys Acta 1803, 639-40.

Bauerschmitt H., Mick D., Deckers M., Vollmer C., Funes S., Kehrein K., Ott M., Rehling P., Herrmann J. (2010) Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell 21, 1937-44.

van der Laan M., Hutu D., Rehling P. (2010) On the mechanism of preprotein import by the mitochondrial presequence translocase. Biochim Biophys Acta 1803, 732-9.

Chacinska A., van der Laan M., Mehnert C., Guiard B., Mick D., Hutu D., Truscott K., Wiedemann N., Meisinger C., Pfanner N., Rehling P. (2010) Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol Cell Biol 30, 307-18.

2009
Gebert N., Joshi A., Kutik S., Becker T., McKenzie M., Guan X., Mooga V., Stroud D., Kulkarni G., Wenk M., Rehling P., Meisinger C., Ryan M., Wiedemann N., Greenberg M., Pfanner N. (2009) Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr Biol 19, 2133-9.

Wagner K., Rehling P., Sanjuán Szklarz L., Taylor R., Pfanner N., van der Laan M. (2009) Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization. J Mol Biol 392, 855-61.

Odorizzi G., Rehling P. (2009) Membranes and organelles. Curr Opin Cell Biol 21, 481-3.

Wagner K., Mick D., Rehling P. (2009) Protein transport machineries for precursor translocation across the inner mitochondrial membrane. Biochim Biophys Acta 1793, 52-9.

2008
Kutik S., Rissler M., Guan X., Guiard B., Shui G., Gebert N., Heacock P., Rehling P., Dowhan W., Wenk M., Pfanner N., Wiedemann N. (2008) The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol 183, 1213-21.

Wagner K., Gebert N., Guiard B., Brandner K., Truscott K., Wiedemann N., Pfanner N., Rehling P. (2008) The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases. Mol Cell Biol 28, 4251-60.

Gebert N., Chacinska A., Wagner K., Guiard B., Koehler C., Rehling P., Pfanner N., Wiedemann N. (2008) Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep 9, 548-54.

Hutu D., Guiard B., Chacinska A., Becker D., Pfanner N., Rehling P., van der Laan M. (2008) Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase. Mol Biol Cell 19, 2642-9.

Stuart R., Rehling P. (2008) Mitochondrial biogenesis: is an old dog still teaching us new tricks? Meeting on the Assembly of the Mitochondrial Respiratory Chain. EMBO Rep 9, 33-8.

2007
Wiedemann N., van der Laan M., Hutu D., Rehling P., Pfanner N. (2007) Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain. J Cell Biol 179, 1115-22.

Mick D., Wagner K., van der Laan M., Frazier A., Perschil I., Pawlas M., Meyer H., Warscheid B., Rehling P. (2007) Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly. EMBO J 26, 4347-58.

van der Laan M., Meinecke M., Dudek J., Hutu D., Lind M., Perschil I., Guiard B., Wagner R., Pfanner N., Rehling P. (2007) Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat Cell Biol 9, 1152-9.

Reinders J., Wagner K., Zahedi R., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6, 1896-906.

2006
van der Laan M., Wiedemann N., Mick D., Guiard B., Rehling P., Pfanner N. (2006) A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria. Curr Biol 16, 2271-6.

Albrecht R., Rehling P., Chacinska A., Brix J., Cadamuro S., Volkmer R., Guiard B., Pfanner N., Zeth K. (2006) The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. EMBO Rep 7, 1233-8.

van der Laan M., Rissler M., Rehling P. (2006) Mitochondrial preprotein translocases as dynamic molecular machines. FEMS Yeast Res 6, 849-61.

Meinecke M., Wagner R., Kovermann P., Guiard B., Mick D., Hutu D., Voos W., Truscott K., Chacinska A., Pfanner N., Rehling P. (2006) Tim50 maintains the permeability barrier of the mitochondrial inner membrane. Science 312, 1523-6.

Frazier A., Taylor R., Mick D., Warscheid B., Stoepel N., Meyer H., Ryan M., Guiard B., Rehling P. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172, 553-64.

Wiedemann N., Pfanner N., Rehling P. (2006) Import of precursor proteins into isolated yeast mitochondria. Methods Mol Biol 313, 373-83.

2005
Brandner K., Mick D., Frazier A., Taylor R., Meisinger C., Rehling P. (2005) Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Mol Biol Cell 16, 5202-14.

van der Laan M., Chacinska A., Lind M., Perschil I., Sickmann A., Meyer H., Guiard B., Meisinger C., Pfanner N., Rehling P. (2005) Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol Cell Biol 25, 7449-58.

Chacinska A., Lind M., Frazier A., Dudek J., Meisinger C., Geissler A., Sickmann A., Meyer H., Truscott K., Guiard B., Pfanner N., Rehling P. (2005) Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-29.

Brandner K., Rehling P., Truscott K. (2005) The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase. J Biol Chem 280, 6215-21.

2004
Rehling P., Brandner K., Pfanner N. (2004) Mitochondrial import and the twin-pore translocase. Nat Rev Mol Cell Biol 5, 519-30.

Li Y., Dudek J., Guiard B., Pfanner N., Rehling P., Voos W. (2004) The presequence translocase-associated protein import motor of mitochondria. Pam16 functions in an antagonistic manner to Pam18. J Biol Chem 279, 38047-54.

Frazier A., Dudek J., Guiard B., Voos W., Li Y., Lind M., Meisinger C., Geissler A., Sickmann A., Meyer H., Bilanchone V., Cumsky M., Truscott K., Pfanner N., Rehling P. (2004) Pam16 has an essential role in the mitochondrial protein import motor. Nat Struct Mol Biol 11, 226-33.

2003
Truscott K., Voos W., Frazier A., Lind M., Li Y., Geissler A., Dudek J., Müller H., Sickmann A., Meyer H., Meisinger C., Guiard B., Rehling P., Pfanner N. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163, 707-13.

Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R., Meyer H., Schönfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100, 13207-12.

Frazier A., Chacinska A., Truscott K., Guiard B., Pfanner N., Rehling P. (2003) Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. Mol Cell Biol 23, 7818-28.

Chacinska A., Rehling P., Guiard B., Frazier A., Schulze-Specking A., Pfanner N., Voos W., Meisinger C. (2003) Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J 22, 5370-81.

Agne B., Meindl N., Niederhoff K., Einwächter H., Rehling P., Sickmann A., Meyer H., Girzalsky W., Kunau W. (2003) Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell 11, 635-46.

Rehling P., Model K., Brandner K., Kovermann P., Sickmann A., Meyer H., Kühlbrandt W., Wagner R., Truscott K., Pfanner N. (2003) Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299, 1747-51.

Rehling P., Pfanner N., Meisinger C. (2003) Insertion of hydrophobic membrane proteins into the inner mitochondrial membrane–a guided tour. J Mol Biol 326, 639-57.