{"id":4707,"date":"2021-07-18T12:39:49","date_gmt":"2021-07-18T10:39:49","guid":{"rendered":"https:\/\/biochemie2.uni-goettingen.de\/?page_id=4707"},"modified":"2026-01-19T09:40:03","modified_gmt":"2026-01-19T08:40:03","slug":"publications-dennerlein","status":"publish","type":"page","link":"https:\/\/biochemie.uni-goettingen.de\/index.php\/publications-dennerlein\/","title":{"rendered":"Publications (Dennerlein)"},"content":{"rendered":"

Publications (since 2007)<\/b><\/h3>\n

2026<\/b>
\nDobrowolska B, Huertas-Zurriaga A, Casanovas-Cu\u00e9llar C, Dziurka M, Garcia-L\u00f3pez C, Herbstreit S, M\u00e4ker D, Ozdoba P, Mart\u00ednez-Gaitero C, Cabrera E; 4D Project Consortium; #The 4D Project Consortium Partners are as follows: Coordinators of the 4D Project. (2026) Exploring barriers and facilitators to mobile technology integration in clinical education: A focus group study with students and stakeholders. Med Teach.<\/b> 2026 Jan 13:1-14.<\/a><\/p>\n

Huertas-Zurriaga A, Dobrowolska B, Chrzan-Rodak A, Fessl A, Dennerlein S, Herbstreit S, Mart\u00ednez-Gaitero C, Cabrera E; on the behalf of 4D Project Consortium. (2026) Facilitators and Barriers to Adoption of Mobile Learning Technologies in Undergraduate Health Professional Education in Clinical Environments: A Scoping Review. J Med Syst.<\/b> 2026 Jan 3;50(1):3.<\/a><\/p>\n

2025<\/b>
\nStoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, G\u00e4rtner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S. (2025) Super-resolution microscopy of mitochondrial mRNAs. Nat Commun.<\/b> 2025 Jul 10;16(1):6391.<\/a><\/p>\n

Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P. (2025) Silencing mitochondrial gene expression in living cells. Science.<\/b> 2025 May 22;389(6759):eadr3498.<\/a><\/p>\n

\u00d6zdemir M, Oeljeklaus S, Schendzielorz A, Morgenstern M, Valpadashi A, Yousefi R, Warscheid B, Dennerlein S (2025) Definition of the human mitochondrial TOM interactome reveals TRABD as a new interacting protein. J Cell Sci.<\/b> 2025 May 1;138(9):jcs263576. Epub 2025 Apr 24.<\/a><\/p>\n

Oborsk\u00e1-Oplov\u00e1 M, Geiger AG, Michel E, Klingauf-Nerurkar P, Dennerlein S, Bykov YS, Amodeo S, Schneider A, Schuldiner M, Rehling P, Panse VG (2025) An avoidance segment resolves a lethal nuclear-mitochondrial targeting conflict during ribosome assembly. Nat Cell Biol.<\/b> 2025 Feb;27(2):336-346. Epub 2025 Jan 31.<\/a><\/p>\n

2024<\/b>
\nShumanska M, Lodygin D, Gibhardt CS, Ickes C, Stejerean-Todoran I, Krause LCM, Pahl K, Jacobs LJHC, Paluschkiwitz A, Liu S, Boshnakovska A, Voigt N, Legler TJ, Haubrock M, Mitkovski M, Poschmann G, Rehling P, Dennerlein S, Riemer J, Fl\u00fcgel A, Bogeski I (2024) Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses. EMBO Rep<\/b> 26(2):407-442.<\/a><\/p>\n

Yousefi R, Dennerlein S (2024) Analysis of mitochondrial translation using click chemistry. Methods Enzymol<\/b> 706, 533-547.<\/a><\/p>\n

\u00d6zdemir M, Dennerlein S (2024) The TOM complex from an evolutionary perspective and the functions of TOMM70. Biol Chem<\/b> 2024 Aug 2.<\/a><\/p>\n

Stephan T, Stoldt S, Barbot M, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S (2024) Drosophila MIC10b can polymerize into cristae-shaping filaments. Life Sci Alliance<\/b> 7(4):e202302177.<\/a><\/p>\n

Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Mol Cell<\/strong> 84(2):345-358.e5.<\/a><\/p>\n

2023
\n<\/b>Dennerlein S, Rehling P, Richter-Dennerlein R (2023) Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1. FEBS Lett<\/b> 597(12):1569-1578.<\/a><\/p>\n

2022<\/b>
\nNadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R (2022) Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control. Nat Commun<\/b> 13, 6406.<\/a><\/p>\n

Fan Y, Murgia M, Linder MI, Mizoguchi Y, Wang C, \u0141yszkiewicz M, Zi\u0229tara N, Liu Y, Frenz S, Sciuccati G, Partida-Gaytan A, Alizadeh Z, Rezaei N, Rehling P, Dennerlein S, Mann M, Klein C (2022) HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation. J Clin Invest<\/b> 132(9):e153153.<\/a><\/p>\n

2021<\/b>
\nDennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P (2021) Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. Elife<\/b> 10:e68213.<\/a><\/p>\n

Segelcke D, Fischer HK, H\u00fctte M, Dennerlein S, Benseler F, Brose N, Pogatzki-Zahn EM, Schmidt M (2021) Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice. Cell Rep<\/b> 37, 110152.<\/a><\/p>\n

Morgenstern M, Peikert CD, L\u00fcbbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, M\u00fchlh\u00e4user WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B (2021) Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell Metab<\/b> 33(12):2464-2483.e18.<\/a><\/p>\n

Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Sch\u00f6ndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P (2021) An in vitro system to silence mitochondrial gene expression. Cell<\/b> 184, 5824-5837.e15.<\/a><\/p>\n

Walter C, Marada A, Suhm T, Ernsberger R, Muders V, K\u00fcc\u00fckk\u00f6se C, S\u00e1nchez-Mart\u00edn P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, V\u00f6gtle FN, Meisinger C (2021) Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nat Commun<\/b> 12, 4284.<\/a><\/p>\n

Almeida L, Dhillon-LaBrooy A, Castro CN, Adossa N, Carriche GM, Guderian M, Lippens S, Dennerlein S, Hesse C, Lambrecht BN, Berod L, Schauser L, Blazar BR, Kalesse M, M\u00fcller R, Moita LF, Sparwasser T (2021) Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity<\/b> 54, 68-83.e6.<\/a><\/p>\n

K\u00fcc\u00fckk\u00f6se C, Taskin AA, Marada A, Brummer T, Dennerlein S, V\u00f6gtle FN (2021) Functional coupling of presequence processing and degradation in human mitochondria. FEBS J<\/b> 288, 600-613.<\/a><\/p>\n

2020<\/b>
\nPacheu-Grau D, Wasilewski M, Oeljeklaus S, Gibhardt CS, Aich A, Chudenkova M, Dennerlein S, Deckers M, Bogeski I, Warscheid B, Chacinska A, Rehling P (2020) COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria. J Mol Biol<\/b> 432, 2067-2079.<\/a><\/p>\n

Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P (2020) MITRAC15\/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep<\/b> 21, e48833.<\/a><\/p>\n

2019<\/b>
\nMohanraj K, Wasilewski M, Beninc\u00e1 C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A (2019) Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7. EMBO Mol Med<\/b> 11(5):e9561.<\/a><\/p>\n

Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P (2019) ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. J Cell Biol<\/b> 218, 598-614.<\/a><\/p>\n

2018<\/b>
\nMandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF (2018) The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Sci Rep<\/b> 8, 16913.<\/a><\/p>\n

Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO (2018) Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nat Commun<\/b> 9, 4230.<\/a><\/p>\n

Callegari S, Dennerlein S (2018) Sensing the Stress: A Role for the UPRmt<\/sup> and UPRam<\/sup> in the Quality Control of Mitochondria. Front Cell Dev Biol<\/b> 6, 31.<\/a><\/p>\n

Aich A, Wang C, Chowdhury A, Rons\u00f6r C, Pacheu-Grau D, Richter-Dennerlein R, Dennerlein S, Rehling P (2018) COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Elife<\/b> 7:e32572.<\/a><\/p>\n

Lorenzi I, Oeljeklaus S, Aich A, Rons\u00f6r C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P (2018) The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Biochim Biophys Acta Mol Cell Res<\/b> 1865, 323-333.<\/a><\/p>\n

2017<\/b>
\nPeri\u0107 M, Lovri\u0107 A, \u0160ari\u0107 A, Musa M, Bou Dib P, Rudan M, Nikoli\u0107 A, Sobo\u010danec S, Mikecin AM, Dennerlein S, Milo\u0161evi\u0107 I, Vlahovi\u010dek K, Raimundo N, Kri\u0161ko A (2017) TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan. Aging Cell<\/b> 16, 994-991005.<\/a><\/p>\n

Dennerlein S, Wang C, Rehling P (2017) Plasticity of Mitochondrial Translation. Trends Cell Biol<\/b> 27, 712-721.<\/a><\/p>\n

Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, Dudek J (2017) Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects. Autophagy<\/b> 13, 201-211.<\/a><\/p>\n

2016<\/b>
\nRichter-Dennerlein R, Oeljeklaus S, Lorenzi I, Rons\u00f6r C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S (2016) Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell<\/b> 167, 471-483.e10.<\/a><\/p>\n

Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, G\u00fcntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM (2016) Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice. Circ Res<\/b> 119, 1004-1016.<\/a><\/p>\n

Lorenzi I, Oeljeklaus S, Rons\u00f6r C, Bareth B, Warscheid B, Rehling P, Dennerlein S (2016) Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates. Mol Cell Biol<\/b> 36, 2782-2793.<\/a><\/p>\n

Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C, H\u00fcbner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV, H\u00f6bartner C, Bohnsack MT (2016) NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. EMBO J<\/b> 35, 2104-2119.<\/a><\/p>\n

Peri\u0107 M, Bou Dib P, Dennerlein S, Musa M, Rudan M, Lovri\u0107 A, Nikoli\u0107 A, \u0160ari\u0107 A, Sobo\u010danec S, Ma\u010dak \u017d, Raimundo N, Kri\u0161ko A (2016) Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan. Sci Rep<\/b> 6, 28751.<\/a><\/p>\n

Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick DU, Helbig C, Urlaub H, Ott M, Rehling P, Dennerlein S (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell<\/b> 27, 1570-1580.<\/a><\/p>\n

2015<\/b>
\nRichter-Dennerlein R, Dennerlein S, Rehling P (2015) Integrating mitochondrial translation into the cellular context. Nat Rev Mol Cell Biol<\/b> 16, 586-592.<\/a><\/p>\n

Dennerlein S, Oeljeklaus S, Jans D, Hellwig C, Bareth B, Jakobs S, Deckers M, Warscheid B, Rehling P (2015) MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly. Cell Rep<\/b> 12, 1644-1655.<\/a><\/p>\n

Pacheu-Grau D, Bareth B, Dudek J, Juris L, V\u00f6gtle FN, Wissel M, Leary SC, Dennerlein S, Rehling P, Deckers M (2015) Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. Cell Metab<\/b> 21, 823-833.<\/a><\/p>\n

Dennerlein S, Rehling P (2015) Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance. J Cell Sci<\/b> 128, 833-837.<\/a><\/p>\n

2013<\/b>
\nBareth B, Dennerlein S, Mick DU, Nikolov M, Urlaub H, Rehling P (2013) The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Mol Cell Biol<\/b> 33, 4128-4137.<\/a><\/p>\n

2012<\/b>
\nMick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (2012) MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell<\/b> 151, 1528-1541.<\/a><\/p>\n

2010<\/b>
\nRichter R, Pajak A, Dennerlein S, Rozanska A, Lightowlers RN, Chrzanowska-Lightowlers ZM (2010) Translation termination in human mitochondrial ribosomes. Biochem Soc Trans<\/b> 38, 1523-1526.<\/a><\/p>\n

Dennerlein S, Rozanska A, Wydro M, Chrzanowska-Lightowlers ZM, Lightowlers RN (2010) Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. Biochem J<\/b> 430, 551-558.<\/a><\/p>\n

Temperley R, Richter R, Dennerlein S, Lightowlers RN, Chrzanowska-Lightowlers ZM (2010) Hungry codons promote frameshifting in human mitochondrial ribosomes. Science<\/b> 327, 301.<\/a><\/p>\n

2007<\/b>
\nBiscotti MA, Canapa A, Olmo E, Barucca M, Teo CH, Schwarzacher T, Dennerlein S, Richter R, Heslop-Harrison JS (2007) Repetitive DNA, molecular cytogenetics and genome organization in the King scallop (Pecten maximus). Gene<\/b> 406, 91-98.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"folder":[97],"class_list":["post-4707","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/comments?post=4707"}],"version-history":[{"count":30,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4707\/revisions"}],"predecessor-version":[{"id":8340,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4707\/revisions\/8340"}],"wp:attachment":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/media?parent=4707"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/folder?post=4707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}