{"id":4719,"date":"2021-07-18T12:43:53","date_gmt":"2021-07-18T10:43:53","guid":{"rendered":"https:\/\/biochemie2.uni-goettingen.de\/?page_id=4719"},"modified":"2025-07-22T17:35:08","modified_gmt":"2025-07-22T15:35:08","slug":"publications-hauke-hillen","status":"publish","type":"page","link":"https:\/\/biochemie.uni-goettingen.de\/index.php\/publications-hauke-hillen\/","title":{"rendered":"Publications (Hauke Hillen)"},"content":{"rendered":"

Publications (since 2017)<\/b><\/h3>\n

2025<\/b>
\nAntonicka H, Vu\u010dkovi\u0107 A, Weraarpachai W, Hong S, Brischigliaro M, Ahn A, Barrientos A, Hillen HS, Shoubridge EA. (2025) FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites. Nucleic Acids Res.<\/b> 2025 Jul 8;53(13):gkaf665.<\/a><\/p>\n

Ahrens FM, do Prado PFV, Hillen HS, Pfannschmidt T. (2025) The plastid-encoded RNA polymerase of plant chloroplasts. Trends Plant Sci.<\/b> 2025 Jul;30(7):712-723.<\/a><\/p>\n

Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R (2025) Coupling of ribosome biogenesis and translation initiation in human mitochondria. Nat Commun.<\/b> 2025 Apr 17;16(1):3641.<\/a><\/p>\n

Bhatta A, Kuhle B, Yu RD, Spanaus L, Ditter K, Bohnsack KE, Hillen HS (2025) Molecular basis of human nuclear and mitochondrial tRNA 3′ processing. Nat Struct Mol Biol.<\/b> 2025 Apr;32(4):613-624. Epub 2025 Jan 2.<\/a><\/p>\n

Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS (2025) Author Correction: Structural basis of Nipah virus RNA synthesis. Nat Commun.<\/b> 2025 Mar 27;16(1):3006.<\/a><\/p>\n

Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS (2025) Structural basis of Nipah virus RNA synthesis. Nat Commun.<\/b> 2025 Mar 6;16(1):2261.<\/a><\/p>\n

Ahrens FM, do Prado PFV, Hillen HS, Pfannschmidt T (2025) The plastid-encoded RNA polymerase of plant chloroplasts. Trends Plant Sci.<\/b> 2025 Feb 25:S1360-1385(25)00031-7.<\/a><\/p>\n

2024<\/b>
\nVu\u010dkovi\u0107 A, Freyer C, Wredenberg A, Hillen HS (2024) The molecular machinery for maturation of primary mtDNA transcripts. Hum Mol Genet.<\/b> 2024 May 22;33(R1):R19-R25.<\/a><\/p>\n

do Prado PFV, Ahrens FM, Liebers M, Ditz N, Braun HP, Pfannschmidt T, Hillen HS (2024) Structure of the multi-subunit chloroplast RNA polymerase. Mol Cell<\/b> 2024 Mar 7;84(5):910-925.e5.<\/a><\/p>\n

2023<\/b>
\nPoerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P (2023) Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Mol Cell<\/b> 84(2):345-358.e5.<\/a><\/p>\n

Hillen HS (2023) Cryo-EM for Structure Determination of Mitochondrial Ribosome Samples. Methods Mol Biol<\/b> 2661, 89-8100.<\/a><\/p>\n

Wohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-B\u00fcrgi S, Amberger A, Hillen HS, Zschocke J, Keller MA (2023) Correction to: Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism. Cell Mol Life Sci<\/b> 80, 37.<\/a><\/p>\n

2022<\/b>
\nWohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-B\u00fcrgi S, Amberger A, Hillen HS, Zschocke J, Keller MA (2022) ost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism. Cell Mol Life Sci<\/b> 79, 562.<\/a><\/p>\n

B\u00f6gershausen N, Krawczyk HE, Jamra RA, Lin SJ, Yigit G, H\u00fcning I, Polo AM, Vona B, Huang K, Schmidt J, Altm\u00fcller J, Luppe J, Platzer K, D\u00f6rgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, B\u00fcltmann E, N\u00fcrnberg P, Spielmann M, Lemke JR, Li Y, Zenker M, Varshney GK, Hillen HS, Kratz CP, Wollnik B (2022) WARS1 and SARS1: two tRNA synthetases implicated in autosomal recessive microcephaly. Hum Mutat <\/b>43(10):1454-1471<\/a>.<\/p>\n

Bhatta A, Hillen HS (2022) Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes. Trends Biochem Sci<\/b> 47(11):965-977.<\/a><\/p>\n

2021<\/b>
\nLavdovskaia E, Hillen HS, Richter-Dennerlein R (2021) Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis. Trends Cell Biol<\/b> 32(3):182-185.<\/a><\/p>\n

Bhatta A, Dienemann C, Cramer P, Hillen HS (2021) Structural basis of RNA processing by human mitochondrial RNase P. Nat Struct Mol Biol<\/b> 28, 713-723.<\/a><\/p>\n

Jochheim FA, Tegunov D, Hillen HS, Schmitzov\u00e1 J, Kokic G, Dienemann C, Cramer P (2021) The structure of a dimeric form of SARS-CoV-2 polymerase. Commun Biol<\/b> 4, 999.<\/a><\/p>\n

Kabinger F, Stiller C, Schmitzov\u00e1 J, Dienemann C, Kokic G, Hillen HS, H\u00f6bartner C, Cramer P (2021) Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat Struct Mol Biol<\/b> 28, 740-746.<\/a><\/p>\n

Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R (2021) Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nat Commun<\/b> 12, 3672.<\/a><\/p>\n

Hillen HS (2021) Structure and function of SARS-CoV-2 polymerase. Curr Opin Virol<\/b> 48, 82-90.<\/a><\/p>\n

Hillen HS, Markov DA, Wojtas ID, Hofmann KB, Lidschreiber M, Cowan AT, Jones JL, Temiakov D, Cramer P, Anikin M (2021) The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proc Natl Acad Sci U S A<\/b> 118(15):e2009329118.<\/a><\/p>\n

Cramer P, Kokic G, Dienemann C, H\u00f6bartner C, Hillen HS (2021) Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir. Biospektrum (Heidelb)<\/b> 27, 49-53.<\/a><\/p>\n

Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, H\u00f6bartner C, Cramer P (2021) Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun<\/b> 12, 279.<\/a><\/p>\n

2020<\/b>
\nBonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG (2020) Small-molecule inhibitors of human mitochondrial DNA transcription. Nature<\/b> 588, 712-716.<\/a><\/p>\n

Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P (2020) Structure of replicating SARS-CoV-2 polymerase. Nature<\/b> 584, 154-156.<\/a><\/p>\n

2019<\/b>
\nGrimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, H\u00fcttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, B\u00f6ttcher B, Szalay AA, Cramer P, Fischer U (2019) Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes. Cell<\/b> 179, 1537-1550.e19.<\/a><\/p>\n

Hillen HS, Bartuli J, Grimm C, Dienemann C, Bedenk K, Szalay AA, Fischer U, Cramer P (2019) Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes. Cell<\/b> 179, 1525-1536.e12.<\/a><\/p>\n

2018<\/b>
\nHillen HS, Temiakov D, Cramer P (2018) Structural basis of mitochondrial transcription. Nat Struct Mol Biol<\/b> 25, 754-765.<\/a><\/p>\n

2017<\/b>
\nHillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P (2017) Structural Basis of Mitochondrial Transcription Initiation. Cell<\/b> 171, 1072-1081.e10.<\/a><\/p>\n

Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D (2017) Mechanism of Transcription Anti-termination in Human Mitochondria. Cell<\/b> 171, 1082-1093.e13.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"folder":[89],"class_list":["post-4719","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/comments?post=4719"}],"version-history":[{"count":24,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4719\/revisions"}],"predecessor-version":[{"id":8114,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4719\/revisions\/8114"}],"wp:attachment":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/media?parent=4719"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/folder?post=4719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}