{"id":4805,"date":"2021-07-19T13:40:21","date_gmt":"2021-07-19T11:40:21","guid":{"rendered":"https:\/\/biochemie2.uni-goettingen.de\/?page_id=4805"},"modified":"2026-01-27T10:06:45","modified_gmt":"2026-01-27T09:06:45","slug":"publications-kehlenbach","status":"publish","type":"page","link":"https:\/\/biochemie.uni-goettingen.de\/index.php\/publications-kehlenbach\/","title":{"rendered":"Publications (Kehlenbach)"},"content":{"rendered":"

Publications (since 2003)<\/b><\/h3>\n

2026<\/strong>
\nKohlhause D, Spillner C, Zapata VA, Lenz C, Urlaub H, Kohl T, Lehnart SE, Gerace L, Kehlenbach RH. (2026). The nuclear envelope protein TMEM209 is an integral component of the nuclear pore complex and interacts with Nup210. J Cell Sci.<\/strong> 2026 Jun 15;139(12):jcs264298. Epub 2026 Jan 15.<\/a><\/p>\n

Rodr\u00edguez-Gonz\u00e1lez I, Kohlhause D, Lenz C, Urlaub H, Spillner C, Kehlenbach RH. (2026). VAPA at the inner nuclear membrane affects nuclear lamins and nuclear morphology. J Cell Sci.<\/strong> 2026 Jan 26:jcs.264534.<\/a><\/p>\n

2025
\n<\/strong>Kehlenbach RH, Chook YM. (2025). The nuclear export receptor CRM1\/XPO1 and its diverse cargoes. Trends Biochem Sci.<\/strong> 2025 Dec;50(12):1131-1144.<\/a><\/p>\n

2024
\n<\/strong>James C, M\u00f6ller U, Spillner C, K\u00f6nig S, Dybkov O, Urlaub H, Lenz C, Kehlenbach RH (2024). Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis. EMBO Rep.<\/strong> 25(5):2391-2417.<\/a><\/p>\n

2023<\/b>
\nKehlenbach RH, Neumann P, Ficner R, Dickmanns A (2023) Interaction of nucleoporins with nuclear transport receptors: a structural perspective. Biol Chem<\/b> 404(8-9):791-805.<\/a><\/p>\n

P\u00f6rschke M, Rodr\u00edguez-Gonz\u00e1lez I, Parfentev I, Urlaub H, Kehlenbach RH (2023) Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein. J Biol Chem<\/b> , 102932.<\/a><\/p>\n

2022<\/b>
\nJames C, Lenz C, Kehlenbach RH (2022) RAPIDS, a method for sub-compartmental identification of protein interactomes. Methods Enzymol<\/b> 675, 109-130.<\/a><\/p>\n

2021<\/b>
\nJames C, Lenz C, Urlaub H, Kehlenbach RH (2021) Sequestosome 1 Is Part of the Interaction Network of VAPB. Int J Mol Sci<\/b> 22(24):13271.<\/a><\/p>\n

Lagadec F, Carlon-Andres I, Ragues J, Port S, Wodrich H, Kehlenbach RH (2021) CRM1 promotes capsid disassembly and nuclear envelope translocation of adenovirus independently of its export function. J Virol<\/b> , JVI0127321.<\/a><\/p>\n

James C, Kehlenbach RH (2021) The Interactome of the VAP Family of Proteins: An Overview. Cells<\/b> 10(7):1780.<\/a><\/p>\n

Baade I, Hutten S, Sternburg EL, P\u00f6rschke M, Hofweber M, Dormann D, Kehlenbach RH (2021) The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors. J Biol Chem<\/b> 296, 100659.<\/a><\/p>\n

Hamed M, Caspar B, Port SA, Kehlenbach RH (2021) A nuclear export sequence promotes CRM1-dependent targeting of the nucleoporin Nup214 to the nuclear pore complex. J Cell Sci<\/b> 134(6):jcs258095.<\/a><\/p>\n

2020<\/b>
\nChizhik AI, Chizhik AM, Ruhlandt D, Pfaff J, Karedla N, Gregor I, Kehlenbach RH, Enderlein J (2020) Dual-Color Metal-Induced Energy Transfer (MIET) Imaging for Three-Dimensional Reconstruction of Nuclear Envelope Architecture. Methods Mol Biol<\/b> 2175, 33-45.<\/a><\/p>\n

Lavau CP, Aumann WK, Sze SK, Gupta V, Ripple K, Port SA, Kehlenbach RH, Wechsler DS (2020) The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice. PLoS One<\/b> 15, e0232036.<\/a><\/p>\n

Carlon-Andres I, Lagadec F, Pied N, Rayne F, Lafon ME, Kehlenbach RH, Wodrich H (2020) Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import. J Virol<\/b> 94(10):e00164-20.<\/a><\/p>\n

M\u00fcller M, James C, Lenz C, Urlaub H, Kehlenbach RH (2020) Probing the Environment of Emerin by Enhanced Ascorbate Peroxidase 2 (APEX2)-Mediated Proximity Labeling. Cells<\/b> 9(3):605.<\/a><\/p>\n

Ashkenazy-Titelman A, Shav-Tal Y, Kehlenbach RH (2020) Into the basket and beyond: the journey of mRNA through the nuclear pore complex. Biochem J<\/b> 477, 23-44.<\/a><\/p>\n

2019<\/b>
\nJames C, M\u00fcller M, Goldberg MW, Lenz C, Urlaub H, Kehlenbach RH (2019) Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane. J Biol Chem<\/b> 294, 16241-16254.<\/a><\/p>\n

Kindermann B, Valkova C, Kr\u00e4mer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C (2019) The nuclear pore proteins Nup88\/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling. J Biol Chem<\/b> 294, 11741-11750.<\/a><\/p>\n

Blenski M, Kehlenbach RH (2019) Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane. Int J Mol Sci<\/b> 20(2):334.<\/a><\/p>\n

Baade I, Kehlenbach RH (2019) The cargo spectrum of nuclear transport receptors. Curr Opin Cell Biol<\/b> 58, 1-7.<\/a><\/p>\n

2018<\/b>
\nBonnin E, Cabochette P, Filosa A, J\u00fchlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B (2018) Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence. PLoS Genet<\/b> 14, e1007845.<\/a><\/p>\n

Wu K, Wang L, Chen Y, Pirooznia M, Singh K, W\u00e4lde S, Kehlenbach RH, Scott I, Gucek M, Sack MN (2018) GCN5L1 interacts with \u03b1TAT1 and RanBP2 to regulate hepatic \u03b1-tubulin acetylation and lysosome trafficking. J Cell Sci<\/b> 131(22):jcs221036.<\/a><\/p>\n

Komatsu T, Quentin-Froignant C, Carlon-Andres I, Lagadec F, Rayne F, Ragues J, Kehlenbach RH, Zhang W, Ehrhardt A, Bystricky K, Morin R, Lagarde JM, Gallardo F, Wodrich H (2018) In Vivo<\/i> Labelling of Adenovirus DNA Identifies Chromatin Anchoring and Biphasic Genome Replication. J Virol<\/b> 92(18):e00795-18.<\/a><\/p>\n

Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach RH, Bailer SM, Dormann D (2018) Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1\/CRM1. Sci Rep<\/b> 8, 7084.<\/a><\/p>\n

Baade I, Spillner C, Schmitt K, Valerius O, Kehlenbach RH (2018) Extensive Identification and In-depth Validation of Importin 13 Cargoes. Mol Cell Proteomics<\/b> 17, 1337-1353.<\/a><\/p>\n

2017<\/b>
\nChizhik AM, Ruhlandt D, Pfaff J, Karedla N, Chizhik AI, Gregor I, Kehlenbach RH, Enderlein J (2017) Three-Dimensional Reconstruction of Nuclear Envelope Architecture Using Dual-Color Metal-Induced Energy Transfer Imaging. ACS Nano<\/b> 11, 11839-11846.<\/a><\/p>\n

2016<\/b>
\nPort SA, Mendes A, Valkova C, Spillner C, Fahrenkrog B, Kaether C, Kehlenbach RH (2016) The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export. J Biol Chem<\/b> 291, 23068-23083.<\/a><\/p>\n

Landry-Voyer AM, Bilodeau S, Bergeron D, Dionne KL, Port SA, Rouleau C, Boisvert FM, Kehlenbach RH, Bachand F (2016) Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors. Mol Cell Biol<\/b> 36, 3019-3032.<\/a><\/p>\n

Kehlenbach RH, Port SA (2016) Analysis of CRM1-Dependent Nuclear Export in Permeabilized Cells. Methods Mol Biol<\/b> 1411, 489-501.<\/a><\/p>\n

Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schr\u00f6der S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E (2016) Distinct functions of the dual leucine zipper kinase depending on its subcellular localization. Cell Signal<\/b> 28, 272-283.<\/a><\/p>\n

Pfaff J, Rivera Monroy J, Jamieson C, Rajanala K, Vilardi F, Schwappach B, Kehlenbach RH (2016) Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane. J Cell Sci<\/b> 129, 502-516.<\/a><\/p>\n

2015<\/b>
\nMonecke T, Dickmanns A, Weiss MS, Port SA, Kehlenbach RH, Ficner R (2015) Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex. Acta Crystallogr F Struct Biol Commun<\/b> 71, 1481-1487.<\/a><\/p>\n

Dickmanns A, Kehlenbach RH, Fahrenkrog B (2015) Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease. Int Rev Cell Mol Biol<\/b> 320, 171-233.<\/a><\/p>\n

Port SA, Monecke T, Dickmanns A, Spillner C, Hofele R, Urlaub H, Ficner R, Kehlenbach RH (2015) Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep<\/b> 13, 690-702.<\/a><\/p>\n

Halder K, D\u00f6lker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubm\u00fcller H, Neumann H (2015) MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-\u03b2. Biophys J<\/b> 109, 277-286.<\/a><\/p>\n

2014<\/b>
\nKimura M, Thakar K, Karaca S, Imamoto N, Kehlenbach RH (2014) Novel approaches for the identification of nuclear transport receptor substrates. Methods Cell Biol<\/b> 122, 353-378.<\/a><\/p>\n

Furuta M, Kose S, Kehlenbach RH, Imamoto N (2014) Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions. Methods Cell Biol<\/b> 122, 331-352.<\/a><\/p>\n

Frohnert C, Hutten S, W\u00e4lde S, Nath A, Kehlenbach RH (2014) Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase. PLoS One<\/b> 9, e88887.<\/a><\/p>\n

2013<\/b>
\nSchulz O, Pieper C, Clever M, Pfaff J, Ruhlandt A, Kehlenbach RH, Wouters FS, Gro\u00dfhans J, Bunt G, Enderlein J (2013) Resolution doubling in fluorescence microscopy with confocal spinning-disk image scanning microscopy. Proc Natl Acad Sci U S A<\/b> 110, 21000-21005.<\/a><\/p>\n

Snow CJ, Dar A, Dutta A, Kehlenbach RH, Paschal BM (2013) Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport. J Cell Biol<\/b> 201, 541-557.<\/a><\/p>\n

Roloff S, Spillner C, Kehlenbach RH (2013) Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1. J Biol Chem<\/b> 288, 3952-3963.<\/a><\/p>\n

Thakar K, Karaca S, Port SA, Urlaub H, Kehlenbach RH (2013) Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry. Mol Cell Proteomics<\/b> 12, 664-678.<\/a><\/p>\n

Ehlers C, Schirmer S, Kehlenbach RH, Hauber J, Chemnitz J (2013) Post-transcriptional regulation of CD83 expression by AUF1 proteins. Nucleic Acids Res<\/b> 41, 206-219.<\/a><\/p>\n

2012<\/b>
\nMalik P, Tabarraei A, Kehlenbach RH, Korfali N, Iwasawa R, Graham SV, Schirmer EC (2012) Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways. J Biol Chem<\/b> 287, 12277-12292.<\/a><\/p>\n

Waldmann I, Spillner C, Kehlenbach RH (2012) The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent nuclear protein export. J Cell Sci<\/b> 125, 144-154.<\/a><\/p>\n

W\u00e4lde S, Thakar K, Hutten S, Spillner C, Nath A, Rothbauer U, Wiemann S, Kehlenbach RH (2012) The nucleoporin Nup358\/RanBP2 promotes nuclear import in a cargo- and transport receptor-specific manner. Traffic<\/b> 13, 218-233.<\/a><\/p>\n

2011<\/b>
\nHamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, W\u00e4lde S, Joseph J, Kehlenbach RH, van Deursen JM (2011) Ran-dependent docking of importin-beta to RanBP2\/Nup358 filaments is essential for protein import and cell viability. J Cell Biol<\/b> 194, 597-612.<\/a><\/p>\n

Pieper D, Schirmer S, Prechtel AT, Kehlenbach RH, Hauber J, Chemnitz J (2011) Functional characterization of the HuR:CD83 mRNA interaction. PLoS One<\/b> 6, e23290.<\/a><\/p>\n

2010<\/b>
\nW\u00e4lde S, Kehlenbach RH (2010) The Part and the Whole: functions of nucleoporins in nucleocytoplasmic transport. Trends Cell Biol<\/b> 20, 461-469.<\/a><\/p>\n

Hilliard M, Frohnert C, Spillner C, Marcone S, Nath A, Lampe T, Fitzgerald DJ, Kehlenbach RH (2010) The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. J Biol Chem<\/b> 285, 22202-22210.<\/a><\/p>\n

Huenniger K, Kr\u00e4mer A, Soom M, Chang I, K\u00f6hler M, Depping R, Kehlenbach RH, Kaether C (2010) Notch1 signaling is mediated by importins alpha 3, 4, and 7. Cell Mol Life Sci<\/b> 67, 3187-3196.<\/a><\/p>\n

2009<\/b>
\nAntony PM, M\u00e4ntele S, Mollenkopf P, Boy J, Kehlenbach RH, Riess O, Schmidt T (2009) Identification and functional dissection of localization signals within ataxin-3. Neurobiol Dis<\/b> 36, 280-292.<\/a><\/p>\n

Hutten S, W\u00e4lde S, Spillner C, Hauber J, Kehlenbach RH (2009) The nuclear pore component Nup358 promotes transportin-dependent nuclear import. J Cell Sci<\/b> 122, 1100-1110.<\/a><\/p>\n

2008<\/b>
\nHutten S, Flotho A, Melchior F, Kehlenbach RH (2008) The Nup358-RanGAP complex is required for efficient importin alpha\/beta-dependent nuclear import. Mol Biol Cell<\/b> 19, 2300-2310.<\/a><\/p>\n

2007<\/b>
\nWaldmann I, W\u00e4lde S, Kehlenbach RH (2007) Nuclear import of c-Jun is mediated by multiple transport receptors. J Biol Chem<\/b> 282, 27685-27692.<\/a><\/p>\n

Hutten S, Kehlenbach RH (2007) CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol<\/b> 17, 193-201.<\/a><\/p>\n

Fries B, Heukeshoven J, Hauber I, Gr\u00fcttner C, Stocking C, Kehlenbach RH, Hauber J, Chemnitz J (2007) Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression. J Biol Chem<\/b> 282, 4504-4515.<\/a><\/p>\n

2006<\/b>
\nHutten S, Kehlenbach RH (2006) Nup214 is required for CRM1-dependent nuclear protein export in vivo. Mol Cell Biol<\/b> 26, 6772-6785.<\/a><\/p>\n

Arnold M, Nath A, Hauber J, Kehlenbach RH (2006) Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. J Biol Chem<\/b> 281, 20883-20890.<\/a><\/p>\n

Sch\u00fctz S, Chemnitz J, Spillner C, Frohme M, Hauber J, Kehlenbach RH (2006) Stimulated expression of mRNAs in activated T cells depends on a functional CRM1 nuclear export pathway. J Mol Biol<\/b> 358, 997-991009.<\/a><\/p>\n

Prechtel AT, Chemnitz J, Schirmer S, Ehlers C, Langbein-Detsch I, St\u00fclke J, Dabauvalle MC, Kehlenbach RH, Hauber J (2006) Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element. J Biol Chem<\/b> 281, 10912-10925.<\/a><\/p>\n

Arnold M, Nath A, Wohlwend D, Kehlenbach RH (2006) Transportin is a major nuclear import receptor for c-Fos: a novel mode of cargo interaction. J Biol Chem<\/b> 281, 5492-5499.<\/a><\/p>\n

2003<\/b>
\nKehlenbach RH (2003) In vitro analysis of nuclear mRNA export using molecular beacons for target detection. Nucleic Acids Res<\/b> 31, e64.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"folder":[109],"class_list":["post-4805","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4805","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/comments?post=4805"}],"version-history":[{"count":18,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4805\/revisions"}],"predecessor-version":[{"id":8348,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/pages\/4805\/revisions\/8348"}],"wp:attachment":[{"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/media?parent=4805"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/biochemie.uni-goettingen.de\/index.php\/wp-json\/wp\/v2\/folder?post=4805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}