since 2003


  • Linden A., Deckers M., Parfentev I., Pflanz R., Homberg B., Neumann P., Ficner R., Rehling P., Urlaub H. (2020) A Cross-Linking Mass Spectrometry Approach Defines Protein Interactions in Yeast Mitochondria. Mol Cell Proteomics 2020 Apr 24;mcp.RA120.002028.  doi: 10.1074/mcp.RA120.002028. Online ahead of print.

    Stephan T., Brüser C., Deckers M., Steyer AM., Balzarotti F., Barbot M., Behr TS., Heim G., Hübner W., Ilgen P., Lange F., Pacheu-Grau D., Pape JK., Stoldt S., Huser T., Hell SW., Möbius W., Rehling P., Riedel D., Jakobs S. (2020) MICOS Assembly Controls Mitochondrial Inner Membrane Remodeling and Crista Junction Redistribution to Mediate Cristae Formation. EMBO J. 2020 Jun 22;e104105.  doi: 10.15252/embj.2019104105.  Online ahead of print.

  • Gomkale R., Cruz-Zaragoza LD., Suppanz I., Guiard B., Montoya J., Callegari S., Pacheu-Grau D., Warscheid B., Rehling P. (2020) Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos. Curr Biol. 2020 Jan 23. pii: S0960-9822(20)30024-5. doi: 10.1016/j.cub.2020.01.024. [Epub ahead of print]

  • Callegari S., Cruz-Zaragoza LD., Rehling P. (2020) From TOM to the TIM23 complex - handing over of a precursor. Biol Chem. 2020 Feb 1. pii: /j/bchm.just-accepted/hsz-2020-0101/hsz-2020-0101.xml. doi: 10.1515/hsz-2020-0101. [Epub ahead of print]

  • Pacheu-Grau D., Wasilewski M., Oeljeklaus S., Gibhardt CS., Aich A., Chudenkova M., Dennerlein S., Deckers M., Bogeski I., Warscheid B., Chacinska A., Rehling P. (2020) COA6 facilitates cytochrome c oxidase biogenesis as thiol-reductase for copper metallochaperones in mitochondria. J Mol Biol. 2020 Feb 13. pii: S0022-2836(20)30102-9. doi: 10.1016/j.jmb.2020.01.036

  • Wang C., Richter-Dennerlein R., Pacheu-Grau D., Liu F., Zhu Y., Dennerlein S., Rehling P. (2020) MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep. 2020 Jan 7;21(1):e48833. doi: 10.15252/embr.201948833. Epub 2019 Nov 13.


  • Zhang X., Gibhardt CS., Will T., Stanisz H., Körbel C., Mitkovski M., Stejerean I., Cappello S., Pacheu-Grau D., Dudek J., Tahbaz N., Mina L., Simmen T., Laschke MW., Menger MD., Schön MP., Helms V., Niemeyer BA., Rehling P., Vultur A, Bogeski I. (2019) Redox signals at the ER-mitochondria interface control melanoma progression. EMBO J. 38:e100871

  • Callegari S., Rehling P. (2019) Guarding the gate for mitochondrial entry. Nature 569, 635-637

  • Can K., Menzfeld C., Rinne L., Rehling P., Kügler S., Golubiani G., Dudek J., Müller M. (2019) Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is
    Accompanied by Intensified Mitochondrial O2 Consumption and ROS Release. Front Physiol 10:479

  • Callegari S., Müller T., Schulz C., Lenz C., Jans DC., Wissel M., Opazo F., Rizzoli SO., Jakobs S., Urlaub H., Rehling P., Deckers M. (2019) A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria. J Mol Biol. 431, 2835-2851

  • Mohanraj K., Wasilewski M., Benincá C., Cysewski D., Poznanski J., Sakowska P., Bugajska Z., Deckers M., Dennerlein S., Fernandez-Vizarra E., Rehling P., Dadlez M., Zeviani M., Chacinska, A. (2019) Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7. EMBO Mol. Med. 11(5). pii: e9561

  • Richter F., Dennerlein S., Nikolov M., Jans DC., Naumenko N., Aich A., MacVicar T., Linden A., Jakobs S., Urlaub H., Langer T., Rehling P. ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. (2019) J Cell Biol. 218, 598-614

  • Antunes D., Chowdhury A., Aich A., Saladi S., Harpaz N., Stahl M., Schuldiner M., Herrmann JM., Rehling P., Rapaport D. (2019) Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1. J Mol Med 97, 269-279

  • Nanadikar MS., Vergel Leon AM., Borowik S., Hillemann A., Zieseniss A., Belousov VV., Bogeski I., Rehling P., Dudek J., Katschinski DM. (2019) O2 affects mitochondrial functionality ex vivo. Redox Biol. 22, 101152

  • Dudek J., Hartmann M., Rehling P. (2019) The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease. Biochim Biophys Acta Mol Basis Dis. 1865, 810-821



  • Saal KA., Richter F., Rehling P., Rizzoli SO. (2018) Combined Use of Unnatural Amino Acids Enables Dual Color Super-Resolution Imaging of Proteins via Click Chemistry. ACS Nano ACS Nano 12, 12247–12254

  • Pacheu-Grau D., Callegari S., Emperador S., Thompson K., Aich A., Topol SE., Spencer E.G., McFarland R., Ruiz-Pesini E., Torkamani A., Taylor R.W., Montoya J., Rehling P. (2018) Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy. Hum Mol Genet. 27 (23), 4135-4144

  • Mandad S., Rahman R.U., Centeno T.P., Vidal R.O., Wildhagen H., Rammner B., Keihani S., Opazo F., Urban I., Ischebeck T., Kirli K., Benito E., Fischer A., Yousefi R.Y., Dennerlein S., Rehling P., Feussner I., Urlaub H., Bonn S., Rizzoli S.O., Fornasiero E.F. (2018) The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Sci Rep. 8 (1),16913

  • Fornasiero E.F., Mandad S., Wildhagen H., Alevra M., Rammner B., Keihani S., Opazo F., Urban I., Ischebeck T., Sakib M.S., Fard M.K., Kirli K., Centeno T.P., Vidal R.O., Rahman R.U., Benito E., Fischer A., Dennerlein S., Rehling P., Feussner I., Bonn S., Simons M., Urlaub H., Rizzoli S.O. (2018) Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nat Commun. 9, 4230

  • Chowdhury A., Aich A., Jain G., Wozny K., Lüchtenborg C., Hartmann M., Bernhard O., Balleiniger M., Alfar E.A., Zieseniss A., Toischer K., Guan K., Rizzoli S.O., Brügger B., Fischer A., Katschinski D.M., Rehling P., Dudek J. (2018) Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1a Expression in Hypoxia. Cell Reports 25, 561–570

  • Schendzielorz, A.B., Bragoszewski, P., Naumenko, N., Gomkale, R., Schulz, C., Guiard, B., Chacinska, A., Rehling, P. (2018) Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane. Nat Commun. 9, 4028

  • Aich, A., Wang, C., Chowdhury, A., Ronsör, C., Pacheu-Grau, D., Richter-Dennerlein, R., Dennerlein, S., Rehling P. (2018) COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Elife. 7. pii: e32572. doi: 10.7554/eLife.32572. [Epub ahead of print]

  • Lorenzi, I., Oeljeklaus, S., Aich, A., Ronsör, C., Callegari, S., Dudek, J., Warscheid, B., Dennerlein, S., Rehling, P. (2018) The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Biochim Biophys Acta. 1865, 323-333

  • Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara, J., Coceano, G., Boyden, ES., Duncan, RR., Hell, SW., Lauterbach, MA., Lehnart, SE., Moser, T., Outeiro, TF., Rehling, P., Schwappach, B., Testa, I., Zapiec, B., Rizzoli, SO. (2018) Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy. EMBO J. 37, 139-159


  • Naumenko, N., Morgenstern, M., Rucktäschel, R., Warscheid, B., Rehling, P. (2017) INA complex liaises the F1Fo-ATP synthase membrane motor modules. Nat Commun. 8, 1237

  • Callegari, S., Oeljeklaus, S., Warscheid, B., Dennerlein S., Thumm, M., Rehling, P.*, and Dudek, J*. (2017) Phospho-ubiquitin-Parkin complex as a marker for mitophagy signaling. Autophagy 13: 201-211.

  • Guentsch, A., Beneke, A., Swain, L., Farhat, K., Nagarajan, S., Wielockx, B., Dudek, J., Rehling, P., Zieseniss, A., Jatho, A., Chong, M., Santos, C., Shah, A.M., and Katschinski, D.M. (2017) PHD2 is a regulator for glycolytic reprogramming in macrophages. Mol. Cell. Biol. 37, 1-17

  • Schendzielorz, A.B., Schulz, C., Lytovchenko, O., Clancy, A., Guiard, B., Ieva, R., van der Laan, M., and Rehling, P. (2017) Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation. J. Cell Biol. 216:83-92

  • Denkert, N., Schendzielorz, A.B., Barbot, M., Versemann, L., Richter, F., Rehling, P.*, and Meinecke, M.* (2017) Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import. eLife Aug 31;6. pii: e28324. doi: 10.7554/eLife.28324.

  • Dennerlein, S., Wang, C., and Rehling, P. (2017) Plasticity of mitochondrial translation. Trends Cell. Biol. 27: 712–721


  • Richter-Dennerlein, R., Oeljeklaus, S., Lorenzi, I., Ronsör, C., Bareth, B., Schendzielorz, AB., Wang, C., Warscheid, B., Rehling, P., Dennerlein, S. (2016) Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell 167, 471-483

  • Lorenzi, I., Oeljeklaus, S., Ronsör, C., Bareth, B., Warscheid, B., Rehling, P., Dennerlein, S. (2016) The ribosome-associated Mba1 escorts Cox2 from insertion machinery to maturing assembly intermediates. Mol Cell Biol. 36, 2782–2793

  • Bareth, B., Nikolov, M., Lorenzi, I., Hildenbeutel, M., Mick, D.U., Helbig, C., Urlaub, H., Ott, M., Rehling, P., Dennerlein, S. (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell 27, 1570-80

  • Levchenko, M., Römpler, K., Wuttke, J.M., Schmidt, B., Neifer, K., Juris, L., Wissel, M. Rehling, P., Deckers, M. (2016)  Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. BBA Mol. Cell Res. 1863, 1624-32

  • Heininger, A. U., Hackert, P., Andreou, A. Z., Boon, K. L., Memet, I., Prior, M., Clancy, A., Schmidt, B., Urlaub, H., Schleiff, E., Sloan, K. E., Deckers, M., Lührmann, R., Enderlein, J., Klostermeier, D., Rehling, P., Bohnsack, M. T. (2016) Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biol, 13, 320-30.

  • Dudek, J., Cheng, I.F., Chowdhury, A., Wozny, K., Balleininger, M., Reinhold, R., Grunau, S., Callegari, S., Toischer, K., Wanders, R.J., Hasenfuß, G., Brügger, B., Guan, K., Rehling, P. (2015) Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med. 8, 139-54

  • Callegari, S., Richter, F., Chojnacka, K., Jans, DC., Lorenzi, I., Pacheu-Grau, D., Jakobs, S., Lenz, C., Urlaub, H., Dudek, J., Chacinska, A., Rehling, P. (2016) TIM29 is a subunit of the human carrier translocase required for protein transport. FEBS Lett. 590, 4147-4158

  • Haag, S., Sloan, KE., Ranjan, N., Warda, AS., Kretschmer, J., Blessing, C., Hübner, B., Seikowski, J., Dennerlein, S., Rehling, P., Rodnina, MV., Höbartner, C., Bohnsack, MT. (2016) NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. EMBO J. 35, 2104-2119.


  • Richter-Dennerlein, R., Dennerlein, S., Rehling, P. (2015) Integrating mitochondrial translation into the cellular context. Nat. Rev. Mol. Cell Biol. 16, 586-92

  • Dennerlein, S., Oeljeklaus, S., Jans, D., Hellwig, C., Bareth, B., Jakobs, S., Deckers, M., Warscheid, B., Rehling, P. (2015), MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly. Cell Rep. 12, 1644-1655

  • Pacheu-Grau, P., Bareth, B., Dudek, J., Juris, L., Vögtle, F.-N., Wissel, M., Leary, S., Dennerlein, S., Rehling, P., Deckers, M. (2015), Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. Cell Metabolism 21, 823-833

  • Melin, J., Kilisch, M., Neumann, P., Lytovchenko, O., Gomkale, R., Schendzielorz, A., Schmidt, B., Liepold, T., Ficner, R., Jahn, O., Rehling, P., Schulz, C. (2015), A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria. Biochim. Biophys. Acta 1850, 1850-9

  • Schulz, C., Schendzielorz, A., Rehling, P. (2015), Unlocking the presequence import pathway. Trends Cell. Biol. 25, 265-275

  • Dennerlein, S., Rehling, P. (2015), Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance. J. Cell Sci. 128, 833-837


  • Schulz, C., Rehling, P. (2014), Cell Biology. Powering the cell cycle. Science 346, 1059-1060

  • Gornicka, A., Bragoszewski, P., Chroscicki, P., Wenz, L.S., Schulz, C., Rehling, P., Chacinska, A. (2014), A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Mol. Biol. Cell 25, 3999-4009

  • Lytovchenko, O., Naumenko, N., Oeljeklaus, S., Schmidt, B., von der Malsburg, K., Deckers, M., Warscheid, B., van der Laan, M., Rehling, P. (2014), The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase. EMBO J. 33, 1624-38

  • Pfanner, N., van der Laan, M., Amati, P., Capaldi, R. A., Caudy, A. A., Chacinska, A., Darshi, M., Deckers, M., Hoppins, S., Icho, T., Jakobs, S., Ji, J., Kozjak-Pavlovic, V., Meisinger, C., Odgren, P. R., Park, S. K., Rehling, P., Reichert, A. S., Sheikh, M. S., Taylor, S. S., Tsuchida, N., van der Bliek, A. M., van der Klei, I. J., Weissman, J. S., Westermann, B., Zha, J., Neupert, W., Nunnari, J. (2014), Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J. Cell. Biol. 204, 1083-1086

  • Melin, J., Schulz, C., Wrobel, L., Bernhard, O., Chacinska, A., Jahn, O., Schmidt, B., Rehling, P. (2014), Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix. Mol. Cell Biol. 34, 3473-85

  • Schulz, C., Rehling, P. (2014), Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation.. Nat. Commun. 5, 4349


  • Dudek, J., Rehling, P., van der Laan, M. (2013), Mitochondrial protein import: Common principles and physiological networks. Biochim. Biophys. Acta 1833, (2), 274-285

  • Bareth, B., Dennerlein, S., Mick, D.U., Nikolov, M., Urlaub, H., Rehling, P. (2013), The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Mol. Cell. Biol. 33, 4128-4137

  • Welter, E., Montino, M., Reinhold, R., Schlotterhose, P., Krick, R., Dudek, J., Rehling, P., Thumm ,M. (2013), Uth1 is a mitochondrial inner membrane protein dispensable for post-log phase and rapamycin-induced mitophagy. FEBS J. 280, 4970-4982

  • Dudek, J., Cheng, I.F., Balleininger, M., Vaz, F.M., Streckfuss-Bömeke, K., Hübscher, D., Vukotic, M., Wanders, R.J., Rehling, P., Guan, K. (2013), Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome. Stem Cell Res. 11, 806-819

  • Jans, D.C., Wurm, C.A., Riedel, D., Wenzel, D., Stagge, F., Deckers, M., Rehling, P., Jakobs, S. (2013), STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria. Proc Natl Acad Sci U S A. 110, 8936-8941

  • Lytovchenko, O., Melin, J., Schulz, C., Kilisch, M., Hutu, D.P., Rehling, P. (2013), Signal recognition initiates reorganization of the presequence translocase during protein import. EMBO J. 32, 886-898


  • Vukotic, M., Oeljeklaus, S., Wiese, S., Vögtle, F.N., Meisinger, C., Meyer, H.E., Zieseniss, A., Katschinski, D.M., Jans, D.C., Jakobs, S., Warscheid, B., Rehling, P., Deckers, M. (2012), Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex. Cell Metab. 15, (3), 336-347

  • Keil, M., Bareth, B., Woellhaf, M.W., Peleh, V., Prestele, M., Rehling, P., Herrmann, J.M. (2012), Oxa1-ribosome complexes coordinate the assembly of cytochrome c oxidase in mitochondria. J. Biol. Chem. 287, (41), 34484-34493

  • Reinhold, R., Krüger, V., Meinecke, M., Schulz, C., Schmidt, B., Grunau, S.D., Guiard, B., Wiedemann, N., van der Laan, M., Wagner, R., Rehling, P., Dudek, J. (2012), The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Mol. Cell. Biol. 32, (24), 5009-5021

  • Krüger, V., Deckers, M., Hildenbeutel, M., van der Laan, M., Hellmers, M., Dreker, C., Preuss, M., Herrmann, J.M., Rehling, P., Wagner, R., Meinecke, M. (2012), The mitochondrial oxidase assembly protein1 (Oxa1) insertase forms a membrane pore in lipid bilayers. J. Biol. Chem. 287, 33314-33326

  • Mick, D. U., Dennerlein, S., Wiese, H, Reinhold, R., Pacheu-Grau, D., Lorenzi, I., Sasarman, F., Weraarpachai, W., Shoubridge, E. A., Warscheid, B. and Rehling, P. (2012), MITRAC Links Mitochondrial Protein Translocation to Respiratory-Chain Assembly and Translational Regulation. Cell 151, 1528–1541


  • Reinhold, R., Bareth, B., Balleininger, M., Wissel, M., Rehling, P., Mick, D.U. (2011), Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Hum. Mol. Genet. 20, (12), 2379-2393

  • Rehling, P. (2011), Tinkering with nature. Nat. Rev. Mol. Cell Biol. 12, (7), 401

  • Mick, D.U., Fox, T.D., Rehling, P. (2011), Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nat. Rev. Mol. Cell Biol. 12, 14-20

  • Lupo, D., Vollmer, C., Deckers, M., Mick, D.U., Tews, I., Sinning, I., Rehling, P. (2011), Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane. Traffic 12, (10), 1457-1466

  • von der Malsburg, K., Müller, J.M., Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J.C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner, N., Chacinska, A., van der Laan, M. (2011), Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev. Cell. 21, (4), 694-707

  • Schulz, C., Lytovchenko, O., Melin, J., Chacinska, A., Guiard, B., Neumann, P., Ficner, R., Jahn, O., Schmidt, B., Rehling, P. (2011), Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex. J. Cell. Biol. 195, 643-656

  • Gebert, N., Gebert, M., Oeljeklaus, S., von der Malsburg, K., Stroud, D.A., Kulawiak, B., Wirth, C., Zahedi, R.P., Dolezal, P., Wiese, S., Simon, O., Schulze-Specking, A., Truscott, K.N., Sickmann, A., Rehling, P., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N. (2011), Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane. Mol. Cell 44, (5), 811-818


  • Van der Laan, M., Hutu, D.P., Rehling, P. (2010), On the mechanism of preprotein import by the mitochondrial presequence translocase. Biochim. Biophys. Acta 1803, (6), 732-739

  • Chacinska, A., van der Laan, M., Mehnert, C.S., Guiard, B., Mick, D.U., Hutu, D.P., Truscott, K.N., Wiedemann, N., Meisinger, C., Pfanner, N., and Rehling, P. (2010), Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol. Cell. Biol. 30, (1), 307-318

  • Bauerschmitt, H., Mick, D.U., Deckers, M., Vollmer, C., Funes, S., Kehrein, K., Ott, M., Rehling, P., and Herrmann, J.M. (2010), Ribosome Binding Proteins Mdm38 and Mba1 Display Overlapping Functions for Regulation of Mitochondrial Translation. Mol. Biol. Cell 21, (12), 1937-1944

  • Rehling, P., Rospert, S. (2010), Molecular chaperones and intracellular protein transport. Biochim. Biophys. Acta 1803, (6), 639-640

  • Bohnert, M., Rehling, P., Guiard, B., Herman, J.M., Pfanner, N., van der Laan, M. (2010), Cooperation of stop-transfer and conservative sorting mechanisms in mitochondrial protein transport. Curr. Biol. 20, 1227-1232

  • Mick, D.U., Vukotic, M., Piechura, H., Meyer, H.E., Warscheid, B., Deckers, M., Rehling, P. (2010), Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria. J. Cell Biol. 191, (1), 141-154


  • Odorizzi, G. and Rehling, P. (2009), Membranes and organelles. Curr. Opin. Cell Biol. 21, 481-483

  • Wagner, K., Mick, D.U., and Rehling, P. (2009), Protein transport machineries for precursor translocation across the inner mitochondrial membrane. Biochim. Biophys.Acta. 1793, 52-59

  • Wagner, K., Rehling, P., Szklarz, L.K., Taylor, R.D., Pfanner, N., and van der Laan, M. (2009), Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization. J. Mol. Biol. 392, (4), 855-861

  • Gebert, N., Joshi, A.S., Kutik, S., Becker, T., McKenzie, M., Guan, X.L., Mooga, V.P., Stroud, D.A., Kulkarni, G., Wenk, M.R., Rehling, P., Meisinger, C., Ryan, M.T., Wiedemann, N., Greenberg, M.L., Pfanner, N. (2009), Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr. Biol. 19, (24), 2133-2139


  • Kutik, S., Rissler, M., Guan, X.L., Guiard, B., Shui, G., Gebert, N., Heacock, P.N., Rehling, P., Dowhan, W., Wenk, M.R., Pfanner, N. and Wiedemann, N. (2008), The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J. Cell Biol. 183, 1213-1221

  • Gebert, N., Chacinska, A., Wagner, K., Guiard, B., Koehler, C.M., Rehling, P., Pfanner, N., and Wiedemann, N. (2008), Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep. 9, 548-554

  • Stuart, R. A. and Rehling, P. (2008), Mitochondrial biogenesis: is an old dog still teaching us new tricks?. EMBO Rep. 9, 33-38

  • Hutu, D. P., Guiard, B., Chacinska, A., Becker, D., Pfanner, N., Rehling, P., and Van der Laan, M. (2008), Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase. Mol. Biol. Cell 19, 2642-2649

  • Wagner, K., Gebert, N., Guiard, B., Brandner, K., Truscott, K.N., Wiedemann, N., Pfanner, N., and Rehling, P. (2008), The Assembly Pathway of the Mitochondrial Carrier Translocase Involves four Preprotein Translocases. Mol. Cell. Biol. 28, 4251-4260


  • Reinders, J., Wagner, K., Zahedi, R.P., Stojanovski, D., Eyrich, B., Van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., and Meisinger, C. (2007), Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol. Cell. Proteomics 6, 1896-1906

  • Mick, D. U., Wagner, K., Van der Laan, M., Frazier, A. E., Perschil, I., Pawlas, M., Meyer, H.E., Warscheid, B., and Rehling, P. (2007), Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly. EMBO J. 26, 4347-4358

  • Van der Laan, M., Meinecke, M., Dudek, J., Hutu, D. P., Lind, M., Perschil, I., Guiard, B., Wagner, R., Pfanner, N., and Rehling, P. (2007), Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat. Cell. Biol. 9, 1152-1159

  • Wiedemann N., van der Laan M., Hutu D.P., Rehling P., and Pfanner N. (2007), Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain. J. Cell. Biol. 179, (6), 1115-1122


  • Meinecke, M., Wagner, R., Kovermann, P., Guiard, B., Mick, D.U., Hutu, D.P., Voos, W., Truscott, K.N., Chacinska, A., Pfanner, N., and Rehling, P. (2006), Tim50 Maintains the Permeability Barrier of the Mitochondrial Inner Membrane. Science 312, 1523-1526

  • Frazier, A.E., Taylor, R., Mick, D.U., Warscheid, B., Stoepel, N., Meyer, H.E., Ryan, M.T., Guiard B., and Rehling, P. (2006), Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J. Cell Biol. 172, 553-564

  • Van der Laan, M., Wiedemann, N., Mick, D.U., Guiard, B., Rehling, P., and Pfanner, N. (2006), A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria. Curr. Biol. 16, 2271-2276

  • van der Laan, M., Rissler, M., and Rehling, P. (2006), Presequence translocase of the inner mitochondrial membrane - an intricate and highly dynamic molecular machine. FEMS Yeast Res. 6, 849-861

  • Albrecht, R., Rehling, P., Chacinska, A., Brix, J., Cadamuro, S.A., Volkmer, R., Guiard, B., Pfanner, N. and Zeth, K. (2006), The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. EMBO Rep. 7, 1233-1238

  • Wiedemann, N., Pfanner, N., and Rehling, P. (2006), Import of precursor proteins into isolated yeast mitochondria. Methods Mol. Biol. 313, 373-384


  • Van der Laan, M., Chacinska, A., Lind, M., Perschil, I., Sickmann, A., Meyer, H.E., Guiard B., Meisinger, C., Pfanner, N., and Rehling, P. (2005), Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol. Cell. Biol. 25, 7449-7458

  • Brandner, K., Mick, D.U., Frazier, A.E., Taylor, R.D., Meisinger, C., and Rehling, P. (2005), Taz1, an Outer Mitochondrial Membrane Protein, Affects Stability and Assembly of Inner Membrane Protein Complexes - Implications for Barth Syndrome. Mol. Biol. Cell. 16, 5202-5214.

  • Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling P. (2005), Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-829

  • Brandner, K., Rehling, P., and Truscott, K.N. (2005), The carboxy-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase. J. Biol. Chem. 280, 6215-6221


  • Frazier, A.E., Dudek, J., Guiard, B., Voos, W., Li, Y., Lind, M., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Bilanchone, V., Cumsky, M.G., Truscott, K.N., Pfanner, N., and Rehling, P. (2004), Pam16 plays an essential role in the presequence translocase-associated protein import motor of mitochondria. Nature Struct. Mol. Biol. 11, 226-233

  • Rehling, P., Brandner, K., and Pfanner, N. (2004), Mitochondrial import and the twin-pore translocase. Nature Rev. Mol. Cell Biol. 5, 519-530

  • Li, Y., Dudek, J., Guiard, B., Pfanner, N., Rehling, P., and Voos, W. (2004), The presequence translocase-associated protein import motor of mitochondria. J. Biol. Chem. 11, 38047-38054

  • Chacinska, A., and Rehling, P. (2004), Moving proteins across and in outer and inner membranes of mitochondria. Biochem. Soc. Trans. 32, 774-776


  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., and Meisinger, C. (2003), The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. USA. 100, 13207-13212

  • Truscott, K.N., Voos, W., Frazier, A., Lind, M., Li, Y., Geissler, A., Dudek, J., Müller, H., Sickmann, A., Meyer, H.E., Meisinger, C., Guiard, B., Rehling, P., and Pfanner, N. (2003), A J-protein is an essential subunit of the presequence translocase associated import motor of mitochondria. J. Cell Biol. 163, 707-713

  • Rehling, P., Model, K., Brandner, K., Kovermann, P., Sickmann, A., Meyer, H.E., Kühlbrandt, W., Wagner, R., Truscott, K.N., and Pfanner, N. (2003), Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299, 1747-1751

  • Frazier, A.E., Chacinska, A., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling, P. (2003), Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. Mol. Cell. Biol. 23, 7818-7828

  • Rehling, P., Pfanner, N., and Meisinger, C. (2003), Insertion of Hydrophobic Membrane Proteins into the Mitochondrial Inner Membrane – A Guided Tour. J. Mol. Biol. 326, 639-657

  • Chacinska, A., Rehling, P., Guiard, B., Frazier A.E., Schulze-Specking, A., Pfanner, N., Voos, W., and Meisinger, C. (2003), Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J. 22, 5370-5381

  • Agne, B., Meindl, N.M., Niederhoff, K., Einwächter, H., Rehling, P., Sickmann, A., Meyer, H.E., Girzalsky, W., and Kunau, W.-H. (2003), Pex8p: An intraperoxisomal organizer of two core complexes of the peroxisomal import machinery. Mol. Cell 11, 635-646