Publications (since 2007)

2024
Shumanska M, Lodygin D, Gibhardt CS, Ickes C, Stejerean-Todoran I, Krause LCM, Pahl K, Jacobs LJHC, Paluschkiwitz A, Liu S, Boshnakovska A, Voigt N, Legler TJ, Haubrock M, Mitkovski M, Poschmann G, Rehling P, Dennerlein S, Riemer J, Flügel A, Bogeski I (2024) Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses. EMBO Rep , .

Yousefi R, Dennerlein S (2024) Analysis of mitochondrial translation using click chemistry. Methods Enzymol 706, 533-547.

Özdemir M, Dennerlein S (2024) The TOM complex from an evolutionary perspective and the functions of TOMM70. Biol Chem , .

Stephan T, Stoldt S, Barbot M, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S (2024) Drosophila MIC10b can polymerize into cristae-shaping filaments. Life Sci Alliance 7, .

Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Mol Cell , .

2023
Dennerlein S, Rehling P, Richter-Dennerlein R (2023) Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1. FEBS Lett , .

2022
Nadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R (2022) Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control. Nat Commun 13, 6406.

Fan Y, Murgia M, Linder MI, Mizoguchi Y, Wang C, Łyszkiewicz M, Ziȩtara N, Liu Y, Frenz S, Sciuccati G, Partida-Gaytan A, Alizadeh Z, Rezaei N, Rehling P, Dennerlein S, Mann M, Klein C (2022) HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation. J Clin Invest 132, .

2021
Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P (2021) Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. Elife 10, .

Segelcke D, Fischer HK, Hütte M, Dennerlein S, Benseler F, Brose N, Pogatzki-Zahn EM, Schmidt M (2021) Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice. Cell Rep 37, 110152.

Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B (2021) Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell Metab , .

Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P (2021) An in vitro system to silence mitochondrial gene expression. Cell 184, 5824-5837.e15.

Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C (2021) Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nat Commun 12, 4284.

Almeida L, Dhillon-LaBrooy A, Castro CN, Adossa N, Carriche GM, Guderian M, Lippens S, Dennerlein S, Hesse C, Lambrecht BN, Berod L, Schauser L, Blazar BR, Kalesse M, Müller R, Moita LF, Sparwasser T (2021) Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity 54, 68-83.e6.

Kücükköse C, Taskin AA, Marada A, Brummer T, Dennerlein S, Vögtle FN (2021) Functional coupling of presequence processing and degradation in human mitochondria. FEBS J 288, 600-613.

2020
Pacheu-Grau D, Wasilewski M, Oeljeklaus S, Gibhardt CS, Aich A, Chudenkova M, Dennerlein S, Deckers M, Bogeski I, Warscheid B, Chacinska A, Rehling P (2020) COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria. J Mol Biol 432, 2067-2079.

Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P (2020) MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep 21, e48833.

2019
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A (2019) Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7. EMBO Mol Med 11, .

Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P (2019) ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. J Cell Biol 218, 598-614.

2018
Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF (2018) The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Sci Rep 8, 16913.

Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO (2018) Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nat Commun 9, 4230.

Callegari S, Dennerlein S (2018) Sensing the Stress: A Role for the UPR^mt and UPR^am in the Quality Control of Mitochondria. Front Cell Dev Biol 6, 31.

Aich A, Wang C, Chowdhury A, Ronsör C, Pacheu-Grau D, Richter-Dennerlein R, Dennerlein S, Rehling P (2018) COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Elife 7, .

Lorenzi I, Oeljeklaus S, Aich A, Ronsör C, Callegari S, Dudek J, Warscheid B, Dennerlein S, Rehling P (2018) The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Biochim Biophys Acta Mol Cell Res 1865, 323-333.

2017
Perić M, Lovrić A, Šarić A, Musa M, Bou Dib P, Rudan M, Nikolić A, Sobočanec S, Mikecin AM, Dennerlein S, Milošević I, Vlahoviček K, Raimundo N, Kriško A (2017) TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan. Aging Cell 16, 994-991005.

Dennerlein S, Wang C, Rehling P (2017) Plasticity of Mitochondrial Translation. Trends Cell Biol 27, 712-721.

Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, Dudek J (2017) Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects. Autophagy 13, 201-211.

2016
Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S (2016) Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell 167, 471-483.e10.

Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM (2016) Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice. Circ Res 119, 1004-1016.

Lorenzi I, Oeljeklaus S, Ronsör C, Bareth B, Warscheid B, Rehling P, Dennerlein S (2016) Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates. Mol Cell Biol 36, 2782-2793.

Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C, Hübner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV, Höbartner C, Bohnsack MT (2016) NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. EMBO J 35, 2104-2119.

Perić M, Bou Dib P, Dennerlein S, Musa M, Rudan M, Lovrić A, Nikolić A, Šarić A, Sobočanec S, Mačak Ž, Raimundo N, Kriško A (2016) Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan. Sci Rep 6, 28751.

Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick DU, Helbig C, Urlaub H, Ott M, Rehling P, Dennerlein S (2016) Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell 27, 1570-1580.

2015
Richter-Dennerlein R, Dennerlein S, Rehling P (2015) Integrating mitochondrial translation into the cellular context. Nat Rev Mol Cell Biol 16, 586-592.

Dennerlein S, Oeljeklaus S, Jans D, Hellwig C, Bareth B, Jakobs S, Deckers M, Warscheid B, Rehling P (2015) MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly. Cell Rep 12, 1644-1655.

Pacheu-Grau D, Bareth B, Dudek J, Juris L, Vögtle FN, Wissel M, Leary SC, Dennerlein S, Rehling P, Deckers M (2015) Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. Cell Metab 21, 823-833.

Dennerlein S, Rehling P (2015) Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance. J Cell Sci 128, 833-837.

2013
Bareth B, Dennerlein S, Mick DU, Nikolov M, Urlaub H, Rehling P (2013) The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Mol Cell Biol 33, 4128-4137.

2012
Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (2012) MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell 151, 1528-1541.

2010
Richter R, Pajak A, Dennerlein S, Rozanska A, Lightowlers RN, Chrzanowska-Lightowlers ZM (2010) Translation termination in human mitochondrial ribosomes. Biochem Soc Trans 38, 1523-1526.

Dennerlein S, Rozanska A, Wydro M, Chrzanowska-Lightowlers ZM, Lightowlers RN (2010) Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. Biochem J 430, 551-558.

Temperley R, Richter R, Dennerlein S, Lightowlers RN, Chrzanowska-Lightowlers ZM (2010) Hungry codons promote frameshifting in human mitochondrial ribosomes. Science 327, 301.

2007
Biscotti MA, Canapa A, Olmo E, Barucca M, Teo CH, Schwarzacher T, Dennerlein S, Richter R, Heslop-Harrison JS (2007) Repetitive DNA, molecular cytogenetics and genome organization in the King scallop (Pecten maximus). Gene 406, 91-98.