Publications (née Sloan) (since 2005)

2023
Bohnsack KE, Yi S, Venus S, Jankowsky E, Bohnsack MT (2023) Cellular functions of eukaryotic RNA helicases and their links to human diseases. Nat Rev Mol Cell Biol , .

Wang C, Ulryck N, Herzel L, Pythoud N, Kleiber N, Guérineau V, Jactel V, Moritz C, Bohnsack MT, Carapito C, Touboul D, Bohnsack KE, Graille M (2023) N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing. Nucleic Acids Res , .

Schuhmacher JS, Tom Dieck S, Christoforidis S, Landerer C, Davila Gallesio J, Hersemann L, Seifert S, Schäfer R, Giner A, Toth-Petroczy A, Kalaidzidis Y, Bohnsack KE, Bohnsack MT, Schuman EM, Zerial M (2023) The Rab5 effector FERRY links early endosomes with mRNA localization. Mol Cell 83, 1839-1855.e13.

Khreiss A, Bohnsack KE, Bohnsack MT (2023) Molecular functions of RNA helicases during ribosomal subunit assembly. Biol Chem , .

Jia J, Hilal T, Bohnsack KE, Chernev A, Tsao N, Bethmann J, Arumugam A, Parmely L, Holton N, Loll B, Mosammaparast N, Bohnsack MT, Urlaub H, Wahl MC (2023) Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex. Nat Commun 14, 1886.

Castro-Hernández R, Berulava T, Metelova M, Epple R, Peña Centeno T, Richter J, Kaurani L, Pradhan R, Sakib MS, Burkhardt S, Ninov M, Bohnsack KE, Bohnsack MT, Delalle I, Fischer A (2023) Conserved reduction of m(6)A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts. Proc Natl Acad Sci U S A 120, e2204933120.

Khreiss A, Capeyrou R, Lebaron S, Albert B, Bohnsack KE, Bohnsack MT, Henry Y, Henras AK, Humbert O (2023) The DEAD-box protein Dbp6 is an ATPase and RNA annealase interacting with the peptidyl transferase center (PTC) of the ribosome. Nucleic Acids Res , .

2022
Chattopadhyay S, Garcia-Martinez J, Haimovich G, Fischer J, Khwaja A, Barkai O, Chuartzman SG, Schuldiner M, Elran R, Rosenberg MI, Urim S, Deshmukh S, Bohnsack KE, Bohnsack MT, Perez-Ortin JE, Choder M (2022) RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway. Nat Commun 13, 7184.

Schneider C, Bohnsack KE (2022) Caught in the act-Visualizing ribonucleases during eukaryotic ribosome assembly. Wiley Interdiscip Rev RNA , e1766.

Bohnsack KE, Henras AK, Nielsen H, Bohnsack MT (2022) Making ends meet: a universal driver of large ribosomal subunit biogenesis. Trends Biochem Sci , .

Bohnsack KE, Kanwal N, Bohnsack MT (2022) Prp43/DHX15 exemplify RNA helicase multifunctionality in the gene expression network. Nucleic Acids Res , .

Farkas Á, Urlaub H, Bohnsack KE, Schwappach B (2022) Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway. J Cell Biol 221, .

Bohnsack KE, Kleiber N, Lemus-Diaz N, Bohnsack MT (2022) Roles and dynamics of 3-methylcytidine in cellular RNAs. Trends Biochem Sci , .

Kleiber N, Lemus-Diaz N, Stiller C, Heinrichs M, Mai MM, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT (2022) The RNA methyltransferase METTL8 installs m³C₃₂ in mitochondrial tRNAs^Thr/Ser(UCN) to optimise tRNA structure and mitochondrial translation. Nat Commun 13, 209.

2021
Aquino GRR, Hackert P, Krogh N, Pan KT, Jaafar M, Henras AK, Nielsen H, Urlaub H, Bohnsack KE, Bohnsack MT (2021) The RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly. Nat Commun 12, 6152.

Jaafar M, Contreras J, Dominique C, Martín-Villanueva S, Capeyrou R, Vitali P, Rodríguez-Galán O, Velasco C, Humbert O, Watkins NJ, Villalobo E, Bohnsack KE, Bohnsack MT, Henry Y, Merhi RA, de la Cruz J, Henras AK (2021) Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast. Nat Commun 12, 6153.

Birikmen M, Bohnsack KE, Tran V, Somayaji S, Bohnsack MT, Ebersberger I (2021) Tracing Eukaryotic Ribosome Biogenesis Factors Into the Archaeal Domain Sheds Light on the Evolution of Functional Complexity. Front Microbiol 12, 739000.

Farkas Á, Bohnsack KE (2021) Capture and delivery of tail-anchored proteins to the endoplasmic reticulum. J Cell Biol 220, e202105004.

Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R (2021) Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nat Commun 12, 3672.

Bohnsack KE, Ficner R, Bohnsack MT, Jonas S (2021) Regulation of DEAH-box RNA helicases by G-patch proteins. Biol Chem 402, 561-579.

Aquino GRR, Krogh N, Hackert P, Martin R, Gallesio JD, van Nues RW, Schneider C, Watkins NJ, Nielsen H, Bohnsack KE, Bohnsack MT (2021) RNA helicase-mediated regulation of snoRNP dynamics on pre-ribosomes and rRNA 2′-O-methylation. Nucleic Acids Res 49, 4066-4084.

Popova B, Wang D, Pätz C, Akkermann D, Lázaro DF, Galka D, Kolog Gulko M, Bohnsack MT, Möbius W, Bohnsack KE, Outeiro TF, Braus GH (2021) DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization. PLoS Genet 17, e1009407.

Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S (2021) Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast. Nat Commun 12, 782.

Choudhury P, Kretschmer J, Hackert P, Bohnsack KE, Bohnsack MT (2021) The DExD box ATPase DDX55 is recruited to domain IV of the 28S ribosomal RNA by its C-terminal region. RNA Biol 18, 1124-1135.

2020
Jia J, Absmeier E, Holton N, Pietrzyk-Brzezinska AJ, Hackert P, Bohnsack KE, Bohnsack MT, Wahl MC (2020) The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. Nat Commun 11, 5535.

Lemus-Diaz N, Ferreira RR, Bohnsack KE, Gruber J, Bohnsack MT (2020) The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27. Nucleic Acids Res 48, 8074-8089.

Davila Gallesio J, Hackert P, Bohnsack KE, Bohnsack MT (2020) Sgd1 is an MIF4G domain-containing cofactor of the RNA helicase Fal1 and associates with the 5′ domain of the 18S rRNA sequence. RNA Biol 17, 539-553.

Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K (2020) Changes in m6A RNA methylation contribute to heart failure progression by modulating translation. Eur J Heart Fail 22, 54-66.

Braun CM, Hackert P, Schmid CE, Bohnsack MT, Bohnsack KE, Perez-Fernandez J (2020) Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit. Nucleic Acids Res 48, 405-420.

2019
Bohnsack KE, Bohnsack MT (2019) RNA-Binding Proteins Chaperone Ribonucleoprotein Complex Assembly to Solve the RNA-Folding Problem. Cell 179, 1248-1250.

van Tran N, Ernst FGM, Hawley BR, Zorbas C, Ulryck N, Hackert P, Bohnsack KE, Bohnsack MT, Jaffrey SR, Graille M, Lafontaine DLJ (2019) The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res 47, 7719-7733.

Bohnsack KE, Bohnsack MT (2019) Uncovering the assembly pathway of human ribosomes and its emerging links to disease. EMBO J 38, e100278.

Bohnsack KE, Höbartner C, Bohnsack MT (2019) Eukaryotic 5-methylcytosine (m⁵C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease. Genes (Basel) 10, 102.

Sloan KE, Knox AA, Wells GR, Schneider C, Watkins NJ (2019) Interactions and activities of factors involved in the late stages of human 18S rRNA maturation. RNA Biol 16, 196-210.

Choudhury P, Hackert P, Memet I, Sloan KE, Bohnsack MT (2019) The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles. RNA Biol 16, 54-68.

2018
Brüning L, Hackert P, Martin R, Davila Gallesio J, Aquino GRR, Urlaub H, Sloan KE, Bohnsack MT (2018) RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes. Nat Commun 9, 5383.

Sednev MV, Mykhailiuk V, Choudhury P, Halang J, Sloan KE, Bohnsack MT, Höbartner C (2018) N⁶ -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes. Angew Chem Int Ed Engl 57, 15117-15121.

Kretschmer J, Rao H, Hackert P, Sloan KE, Höbartner C, Bohnsack MT (2018) The m⁶A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1. RNA 24, 1339-1350.

Bohnsack MT, Sloan KE (2018) Modifications in small nuclear RNAs and their roles in spliceosome assembly and function. Biol Chem 399, 1265-1276.

Sloan KE, Bohnsack MT (2018) Unravelling the Mechanisms of RNA Helicase Regulation. Trends Biochem Sci 43, 237-250.

Bohnsack MT, Sloan KE (2018) The mitochondrial epitranscriptome: the roles of RNA modifications in mitochondrial translation and human disease. Cell Mol Life Sci 75, 241-260.

2017
Warda AS, Kretschmer J, Hackert P, Lenz C, Urlaub H, Höbartner C, Sloan KE, Bohnsack MT (2017) Human METTL16 is a N⁶-methyladenosine (m⁶A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep 18, 2004-2014.

Jungfleisch J, Nedialkova DD, Dotu I, Sloan KE, Martinez-Bosch N, Brüning L, Raineri E, Navarro P, Bohnsack MT, Leidel SA, Díez J (2017) Corrigendum: A novel translational control mechanism involving RNA structures within coding sequences. Genome Res 27, 95-106.

Haag S, Kretschmer J, Sloan KE, Bohnsack MT (2017) Crosslinking Methods to Identify RNA Methyltransferase Targets In Vivo. Methods Mol Biol 1562, 269-281.

Haag S, Sloan KE, Höbartner C, Bohnsack MT (2017) In Vitro Assays for RNA Methyltransferase Activity. Methods Mol Biol 1562, 259-268.

Memet I, Doebele C, Sloan KE, Bohnsack MT (2017) The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis. Nucleic Acids Res 45, 5359-5374.

Wells GR, Weichmann F, Sloan KE, Colvin D, Watkins NJ, Schneider C (2017) The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Nucleic Acids Res 45, 4796-4809.

Sloan KE, Warda AS, Sharma S, Entian KD, Lafontaine DLJ, Bohnsack MT (2017) Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function. RNA Biol 14, 1138-1152.

Jungfleisch J, Nedialkova DD, Dotu I, Sloan KE, Martinez-Bosch N, Brüning L, Raineri E, Navarro P, Bohnsack MT, Leidel SA, Díez J (2017) A novel translational control mechanism involving RNA structures within coding sequences. Genome Res 27, 95-9106.

Sloan KE, Höbartner C, Bohnsack MT (2017) How RNA modification allows non-conventional decoding in mitochondria. Cell Cycle 16, 145-146.

2016
Warda AS, Freytag B, Haag S, Sloan KE, Görlich D, Bohnsack MT (2016) Effects of the Bowen-Conradi syndrome mutation in EMG1 on its nuclear import, stability and nucleolar recruitment. Hum Mol Genet 25, 5353-5364.

Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C, Hübner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV, Höbartner C, Bohnsack MT (2016) NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. EMBO J 35, 2104-2119.

Wells GR, Weichmann F, Colvin D, Sloan KE, Kudla G, Tollervey D, Watkins NJ, Schneider C (2016) The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans. Nucleic Acids Res 44, 9016.

Wells GR, Weichmann F, Colvin D, Sloan KE, Kudla G, Tollervey D, Watkins NJ, Schneider C (2016) The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans. Nucleic Acids Res 44, 5399-5409.

Heininger AU, Hackert P, Andreou AZ, Boon KL, Memet I, Prior M, Clancy A, Schmidt B, Urlaub H, Schleiff E, Sloan KE, Deckers M, Lührmann R, Enderlein J, Klostermeier D, Rehling P, Bohnsack MT (2016) Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biol 13, 320-330.

Sloan KE, Gleizes PE, Bohnsack MT (2016) Nucleocytoplasmic Transport of RNAs and RNA-Protein Complexes. J Mol Biol 428, 2040-2059.

2015
Sloan KE, Leisegang MS, Doebele C, Ramírez AS, Simm S, Safferthal C, Kretschmer J, Schorge T, Markoutsa S, Haag S, Karas M, Ebersberger I, Schleiff E, Watkins NJ, Bohnsack MT (2015) The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21. Nucleic Acids Res 43, 553-564.

2014
Martin R, Hackert P, Ruprecht M, Simm S, Brüning L, Mirus O, Sloan KE, Kudla G, Schleiff E, Bohnsack MT (2014) A pre-ribosomal RNA interaction network involving snoRNAs and the Rok1 helicase. RNA 20, 1173-1182.

Sloan KE, Bohnsack MT, Schneider C, Watkins NJ (2014) The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA. RNA 20, 540-550.

2013
Sloan KE, Bohnsack MT, Watkins NJ (2013) The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Cell Rep 5, 237-247.

Sloan KE, Mattijssen S, Lebaron S, Tollervey D, Pruijn GJ, Watkins NJ (2013) Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing. J Cell Biol 200, 577-588.

2012
Sloan KE, Schneider C, Watkins NJ (2012) Comparison of the yeast and human nuclear exosome complexes. Biochem Soc Trans 40, 850-855.

2011
van Nues RW, Granneman S, Kudla G, Sloan KE, Chicken M, Tollervey D, Watkins NJ (2011) Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing. EMBO J 30, 2420-2430.

2007
Small E, Marrington R, Rodger A, Scott DJ, Sloan K, Roper D, Dafforn TR, Addinall SG (2007) FtsZ polymer-bundling by the Escherichia coli ZapA orthologue, YgfE, involves a conformational change in bound GTP. J Mol Biol 369, 210-221.

2005
Addinall SG, Johnson KA, Dafforn T, Smith C, Rodger A, Gomez RP, Sloan K, Blewett A, Scott DJ, Roper DI (2005) Expression, purification and crystallization of the cell-division protein YgfE from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun 61, 305-307.