Publications (since 2003)

2023
McDowell MA, Heimes M, Enkavi G, Farkas Á, Saar D, Wild K, Schwappach B, Vattulainen I, Sinning I (2023) The GET insertase exhibits conformational plasticity and induces membrane thinning. Nat Commun 14, 7355.

2022
Ballin M, Griep W, Patel M, Karl M, Mentrup T, Rivera-Monroy J, Foo B, Schwappach B, Schröder B (2022) The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins. FEBS J , .

Ulrich K, Farkas Á, Chan O, Katamanin O, Schwappach B, Jakob U (2022) From guide to guard-activation mechanism of the stress-sensing chaperone Get3. Mol Cell , .

Farkas Á, Urlaub H, Bohnsack KE, Schwappach B (2022) Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway. J Cell Biol 221, .

2021
Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, Kilisch M, Schulz C, Cruz-Zaragoza LD, Schwappach B, Ficner R, Jakobs S, Urlaub H, Rehling P (2021) Mapping protein interactions in the active TOM-TIM23 supercomplex. Nat Commun 12, 5715.

Kusch H, Kossen R, Suhr M, Freckmann L, Weber L, Henke C, Lehmann C, Rheinländer S, Aschenbrandt G, Kühlborn LK, Marzec B, Menzel J, Schwappach B, Zelarayán LC, Cyganek L, Antonios G, Kohl T, Lehnart SE, Zoremba M, Sax U, Nussbeck SY (2021) Management of Metadata Types in Basic Cardiological Research. Stud Health Technol Inform 283, 59-68.

Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S (2021) Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast. Nat Commun 12, 782.

Zhang H, Hanson A, de Almeida TS, Emfinger C, McClenaghan C, Harter T, Yan Z, Cooper PE, Brown GS, Arakel EC, Mecham RP, Kovacs A, Halabi CM, Schwappach B, Remedi MS, Nichols CG (2021) Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice. JCI Insight 6, .

Asseck LY, Mehlhorn DG, Monroy JR, Ricardi MM, Breuninger H, Wallmeroth N, Berendzen KW, Nowrousian M, Xing S, Schwappach B, Bayer M, Grefen C (2021) Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes. Proc Natl Acad Sci U S A 118, .

Kraxner J, Lorenz C, Menzel J, Parfentev I, Silbern I, Denz M, Urlaub H, Schwappach B, Köster S (2021) Post-translational modifications soften vimentin intermediate filaments. Nanoscale 13, 380-387.

Ulrich K, Schwappach B, Jakob U (2021) Thiol-based switching mechanisms of stress-sensing chaperones. Biol Chem 402, 239-252.

Fakuade FE, Steckmeister V, Seibertz F, Gronwald J, Kestel S, Menzel J, Pronto JRD, Taha K, Haghighi F, Kensah G, Pearman CM, Wiedmann F, Teske AJ, Schmidt C, Dibb KM, El-Essawi A, Danner BC, Baraki H, Schwappach B, Kutschka I, Mason FE, Voigt N (2021) Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation. Cardiovasc Res 117, 1790-1801.

2020
McDowell MA, Heimes M, Fiorentino F, Mehmood S, Farkas Á, Coy-Vergara J, Wu D, Bolla JR, Schmid V, Heinze R, Wild K, Flemming D, Pfeffer S, Schwappach B, Robinson CV, Sinning I (2020) Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex. Mol Cell 80, 72-86.e7.

Menzel J, Kownatzki-Danger D, Tokar S, Ballone A, Unthan-Fechner K, Kilisch M, Lenz C, Urlaub H, Mori M, Ottmann C, Shattock MJ, Lehnart SE, Schwappach B (2020) 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban. Sci Signal 13, .

Schwappach B (2020) Chloride accumulation in endosomes and lysosomes: facts checked in mice. EMBO J 39, e104812.

Kilisch M, Mayer S, Mitkovski M, Roehse H, Hentrich J, Schwappach B, Papadopoulos T (2020) A GTPase-induced switch in phospholipid affinity of collybistin contributes to synaptic gephyrin clustering. J Cell Sci 133, .

2019
Arakel EC, Huranova M, Estrada AF, Rau EM, Spang A, Schwappach B (2019) Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast. J Cell Sci 132, .

Borgese N, Coy-Vergara J, Colombo SF, Schwappach B (2019) The Ways of Tails: the GET Pathway and more. Protein J 38, 289-305.

Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B (2019) A trap mutant reveals the physiological client spectrum of TRC40. J Cell Sci 132, .

Farkas Á, De Laurentiis EI, Schwappach B (2019) The natural history of Get3-like chaperones. Traffic 20, 311-324.

2018
Ma Y, Ratnasabapathy R, Izzi-Engbeaya C, Nguyen-Tu MS, Richardson E, Hussain S, De Backer I, Holton C, Norton M, Carrat G, Schwappach B, Rutter GA, Dhillo WS, Gardiner J (2018) Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis. Diabetes Obes Metab 20, 2246-2254.

Vitali DG, Sinzel M, Bulthuis EP, Kolb A, Zabel S, Mehlhorn DG, Figueiredo Costa B, Farkas Á, Clancy A, Schuldiner M, Grefen C, Schwappach B, Borgese N, Rapaport D (2018) The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER. J Cell Sci 131, .

Arakel EC, Schwappach B (2018) Correction: Formation of COPI-coated vesicles at a glance (doi:10.1242/jcs.209890). J Cell Sci 131, .

Arakel EC, Schwappach B (2018) Formation of COPI-coated vesicles at a glance. J Cell Sci 131, .

Weill U, Arakel EC, Goldmann O, Golan M, Chuartzman S, Munro S, Schwappach B, Schuldiner M (2018) Toolbox: Creating a systematic database of secretory pathway proteins uncovers new cargo for COPI. Traffic 19, 370-379.

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO (2018) Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy. EMBO J 37, 139-159.

2017
Arakel EC, Schwappach B (2017) Looking inside the cell. Elife 6, .

Geva Y, Crissman J, Arakel EC, Gómez-Navarro N, Chuartzman SG, Stahmer KR, Schwappach B, Miller EA, Schuldiner M (2017) Two novel effectors of trafficking and maturation of the yeast plasma membrane H⁺ -ATPase. Traffic 18, 672-682.

2016
Rivera-Monroy J, Musiol L, Unthan-Fechner K, Farkas Á, Clancy A, Coy-Vergara J, Weill U, Gockel S, Lin SY, Corey DP, Kohl T, Ströbel P, Schuldiner M, Schwappach B, Vilardi F (2016) Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo. Sci Rep 6, 39464.

Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M (2016) The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature 540, 134-138.

Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršič T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T (2016) Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. EMBO J 35, 2536-2552.

Arakel EC, Richter KP, Clancy A, Schwappach B (2016) δ-COP contains a helix C-terminal to its longin domain key to COPI dynamics and function. Proc Natl Acad Sci U S A 113, 6916-6921.

Kilisch M, Lytovchenko O, Arakel EC, Bertinetti D, Schwappach B (2016) A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1. J Cell Sci 129, 831-842.

Pfaff J, Rivera Monroy J, Jamieson C, Rajanala K, Vilardi F, Schwappach B, Kehlenbach RH (2016) Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane. J Cell Sci 129, 502-516.

Brandenburg S, Arakel EC, Schwappach B, Lehnart SE (2016) The molecular and functional identities of atrial cardiomyocytes in health and disease. Biochim Biophys Acta 1863, 1882-1893.

2015
Kilisch M, Lytovchenko O, Schwappach B, Renigunta V, Daut J (2015) The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflugers Arch 467, 1105-1120.

2014
Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U (2014) The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Mol Cell 56, 116-127.

Elbaz-Alon Y, Morgan B, Clancy A, Amoako TN, Zalckvar E, Dick TP, Schwappach B, Schuldiner M (2014) The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis. FEMS Yeast Res 14, 1055-1067.

Nussbeck SY, Weil P, Menzel J, Marzec B, Lorberg K, Schwappach B (2014) The laboratory notebook in the 21st century: The electronic laboratory notebook would enhance good scientific practice and increase research productivity. EMBO Rep 15, 631-634.

Arakel EC, Brandenburg S, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B (2014) Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes. J Cell Sci 127, 2106-2119.

Vilardi F, Stephan M, Clancy A, Janshoff A, Schwappach B (2014) WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane. PLoS One 9, e85033.

2013
Leznicki P, Roebuck QP, Wunderley L, Clancy A, Krysztofinska EM, Isaacson RL, Warwicker J, Schwappach B, High S (2013) The association of BAG6 with SGTA and tail-anchored proteins. PLoS One 8, e59590.

Schuldiner M, Schwappach B (2013) From rags to riches – the history of the endoplasmic reticulum. Biochim Biophys Acta 1833, 2389-2391.

Powis K, Schrul B, Tienson H, Gostimskaya I, Breker M, High S, Schuldiner M, Jakob U, Schwappach B (2013) Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked. J Cell Sci 126, 473-483.

2012
Wolf W, Kilic A, Schrul B, Lorenz H, Schwappach B, Seedorf M (2012) Yeast Ist2 recruits the endoplasmic reticulum to the plasma membrane and creates a ribosome-free membrane microcompartment. PLoS One 7, e39703.

2011
Smith AJ, Daut J, Schwappach B (2011) Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport. Physiology (Bethesda) 26, 181-191.

2010
Simpson PJ, Schwappach B, Dohlman HG, Isaacson RL (2010) Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting. Structure 18, 897-902.

Smith AJ, Schwappach B (2010) Cell biology. Think vesicular chloride. Science 328, 1364-1365.

Braun NA, Morgan B, Dick TP, Schwappach B (2010) The yeast CLC protein counteracts vesicular acidification during iron starvation. J Cell Sci 123, 2342-2350.

Leznicki P, Clancy A, Schwappach B, High S (2010) Bat3 promotes the membrane integration of tail-anchored proteins. J Cell Sci 123, 2170-2178.

2009
Rabu C, Schmid V, Schwappach B, High S (2009) Biogenesis of tail-anchored proteins: the beginning for the end? J Cell Sci 122, 3605-3612.

Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323, 1693-1697.

Zuzarte M, Heusser K, Renigunta V, Schlichthörl G, Rinné S, Wischmeyer E, Daut J, Schwappach B, Preisig-Müller R (2009) Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. J Physiol 587, 929-952.

2008
Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS (2008) The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell 134, 634-645.

Favaloro V, Spasic M, Schwappach B, Dobberstein B (2008) Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. J Cell Sci 121, 1832-1840.

Schwappach B (2008) An overview of trafficking and assembly of neurotransmitter receptors and ion channels (Review). Mol Membr Biol 25, 270-278.

2007
Michelsen K, Schmid V, Metz J, Heusser K, Liebel U, Schwede T, Spang A, Schwappach B (2007) Novel cargo-binding site in the beta and delta subunits of coatomer. J Cell Biol 179, 209-217.

2006
Heusser K, Yuan H, Neagoe I, Tarasov AI, Ashcroft FM, Schwappach B (2006) Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels. J Cell Sci 119, 4353-4363.

Mrowiec T, Schwappach B (2006) 14-3-3 proteins in membrane protein transport. Biol Chem 387, 1227-1236.

Michelsen K, Mrowiec T, Duderstadt KE, Frey S, Minor DL, Mayer MP, Schwappach B (2006) A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Traffic 7, 903-916.

Bundis F, Neagoe I, Schwappach B, Steinmeyer K (2006) Involvement of Golgin-160 in cell surface transport of renal ROMK channel: co-expression of Golgin-160 increases ROMK currents. Cell Physiol Biochem 17, 1-12.

Renigunta V, Yuan H, Zuzarte M, Rinné S, Koch A, Wischmeyer E, Schlichthörl G, Gao Y, Karschin A, Jacob R, Schwappach B, Daut J, Preisig-Müller R (2006) The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1. Traffic 7, 168-181.

Metz J, Wächter A, Schmidt B, Bujnicki JM, Schwappach B (2006) The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol. J Biol Chem 281, 410-417.

2005
Michelsen K, Yuan H, Schwappach B (2005) Hide and run. Arginine-based endoplasmic-reticulum-sorting motifs in the assembly of heteromultimeric membrane proteins. EMBO Rep 6, 717-722.

Heusser K, Schwappach B (2005) Trafficking of potassium channels. Curr Opin Neurobiol 15, 364-369.

Jüschke C, Wächter A, Schwappach B, Seedorf M (2005) SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane. J Cell Biol 169, 613-622.

Neagoe I, Schwappach B (2005) Pas de deux in groups of four–the biogenesis of KATP channels. J Mol Cell Cardiol 38, 887-894.

Wächter A, Schwappach B (2005) The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop. FEBS Lett 579, 1149-1153.

Stegmayer C, Kehlenbach A, Tournaviti S, Wegehingel S, Zehe C, Denny P, Smith DF, Schwappach B, Nickel W (2005) Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant. J Cell Sci 118, 517-527.

2004
Backhaus R, Zehe C, Wegehingel S, Kehlenbach A, Schwappach B, Nickel W (2004) Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding. J Cell Sci 117, 1727-1736.

2003
Yuan H, Michelsen K, Schwappach B (2003) 14-3-3 dimers probe the assembly status of multimeric membrane proteins. Curr Biol 13, 638-646.