Publications (since 2014)

2026
Richter-Dennerlein R, Dopico XC, Rorbach J. (2026) Mechanisms and disease relevance of mitochondrial translation in humans. Nat Rev Mol Cell Biol. 2026 Feb 13; doi: 10.1038/s41580-026-00948-2.

2024
Lavdovskaia E, Hanitsch E, Linden A, Pasen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MMQ, Urlaub H, Liepe J, Richter-Dennerlein R (2024) A roadmap for ribosome assembly in human mitochondria. Nat Struct Mol Biol 2026 Feb 13; doi: 10.1038/s41594-024-01356-w.

Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P (2024) Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Mol Cell 84: 345-358.e5; doi: 10.1016/j.molcel.2023.12.013

2023
Nadler F, Richter-Dennerlein R (2023) Translation termination in human mitochondria – substrate specificity of mitochondrial release factors. Biological Chemistry 404: 769-779; https://doi.org/10.1515/hsz-2023-0127

Dennerlein S, Rehling P, Richter-Dennerlein R (2023) Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1 FEBS Letters 597: 1569–1578

2022
Nadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R (2022) Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control. Nature Communications, 13, 6406

Lavdovskaia E, Hillen HS, Richter-Dennerlein R (2022) Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis. Trends Cell Biol. 32(3): 182-185

Nadler F, Lavdovskaia E, Richter-Dennerlein R (2022) Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors. RNA Biology, 19(1): 117-131

Kleiber N, Lemus-Diaz N, Stiller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack M (2022) The RNA methyltransferase METTL8 installs m³C₃₂ in mitochondrial tRNAs^Thr/Ser(UCN) to optimise tRNA structure and mitochondrial translation. Nature Communications 13, 209

2021
Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P (2021) Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. eLife 10: e68213. doi: 10.7554/eLife.68213

Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk R, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P (2021) An in vitro system to silence mitochondrial gene expression. Cell 184(23): 5824-5837

Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack K, Urlaub H, Richter-Dennerlein R. (2021) Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nature Communications 12, 3672

Maiti P, Lavdovskaia E, Barrientos A, Richter-Dennerlein R (2021) Role of GTPases in Driving Mitoribosome Assembly. Trends Cell Biol. 31(4): 284-297

2020
Lavdovskaia E, Denks K, Nadler F, Steube E, Linden A, Urlaub H, Rodnina M, Richter-Dennerlein R (2020) Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes. Nucleic Acids Research. 48(22):12929–42

Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P (2020) MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep. 21(1):e48833

2018
Lavdovskaia E, Kolander E, Steube E, Mai MMQ, Urlaub H, Richter-Dennerlein R (2018). The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis. Nucleic Acids Research 46, 8471–8482

Aich A, Wang C, Chowdhury A, Ronsör C, Pacheu-Grau D, Richter-Dennerlein R, Dennerlein S, Rehling P (2018) COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Elife 7: e32572. doi: 10.7554/eLife.32572

2017
Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN (2017) The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome. Biochem. J. 474: 2145–2158

2016
Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S (2016) Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell 167: 471–483

König T, Tröder SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, Mühlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T (2016) The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. Mol. Cell 64: 148–162

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger H-G, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T (2016) The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 17: 1844–1856

Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger H-G, Quirós PM, López-Otín C, Rugarli EI, Langer T (2016) Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J. Cell Biol. 212: 157–166

2015
Richter-Dennerlein R, Dennerlein S, Rehling P (2015) Integrating mitochondrial translation into the cellular context. Nat. Rev. Mol. Cell Biol. 16: 586–592

2014
Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T (2014) DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling. Cell Metabolism 20: 158–171