Publications (since 2014)

2024
Lavdovskaia E, Hanitsch E, Linden A, Pasen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MMQ, Urlaub H, Liepe J, Richter-Dennerlein R (2024) A roadmap for ribosome assembly in human mitochondria. Nat Struct Mol Biol; doi: 10.1038/s41594-024-01356-w.

Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P (2024) Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Mol Cell 84: 345-358.e5; doi: 10.1016/j.molcel.2023.12.013

2023
Nadler F, Richter-Dennerlein R (2023) Translation termination in human mitochondria – substrate specificity of mitochondrial release factors. Biological Chemistry 404: 769-779; https://doi.org/10.1515/hsz-2023-0127

Dennerlein S, Rehling P, Richter-Dennerlein R (2023) Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1 FEBS Letters 597: 1569–1578

2022
Nadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R (2022) Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control. Nature Communications, 13, 6406

Lavdovskaia E, Hillen HS, Richter-Dennerlein R (2022) Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis. Trends Cell Biol. 32(3): 182-185

Nadler F, Lavdovskaia E, Richter-Dennerlein R (2022) Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors. RNA Biology, 19(1): 117-131

Kleiber N, Lemus-Diaz N, Stiller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack M (2022) The RNA methyltransferase METTL8 installs m³C₃₂ in mitochondrial tRNAs^Thr/Ser(UCN) to optimise tRNA structure and mitochondrial translation. Nature Communications 13, 209

2021
Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P (2021) Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. eLife 10: e68213. doi: 10.7554/eLife.68213

Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk R, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P (2021) An in vitro system to silence mitochondrial gene expression. Cell 184(23): 5824-5837

Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack K, Urlaub H, Richter-Dennerlein R. (2021) Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nature Communications 12, 3672

Maiti P, Lavdovskaia E, Barrientos A, Richter-Dennerlein R (2021) Role of GTPases in Driving Mitoribosome Assembly. Trends Cell Biol. 31(4): 284-297

2020
Lavdovskaia E, Denks K, Nadler F, Steube E, Linden A, Urlaub H, Rodnina M, Richter-Dennerlein R (2020) Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes. Nucleic Acids Research. 48(22):12929–42

Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P (2020) MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep. 21(1):e48833

2018
Lavdovskaia E, Kolander E, Steube E, Mai MMQ, Urlaub H, Richter-Dennerlein R (2018). The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis. Nucleic Acids Research 46, 8471–8482

Aich A, Wang C, Chowdhury A, Ronsör C, Pacheu-Grau D, Richter-Dennerlein R, Dennerlein S, Rehling P (2018) COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Elife 7: e32572. doi: 10.7554/eLife.32572

2017
Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN (2017) The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome. Biochem. J. 474: 2145–2158

2016
Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S (2016) Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein. Cell 167: 471–483

König T, Tröder SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, Mühlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T (2016) The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. Mol. Cell 64: 148–162

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger H-G, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T (2016) The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 17: 1844–1856

Korwitz A, Merkwirth C, Richter-Dennerlein R, Tröder SE, Sprenger H-G, Quirós PM, López-Otín C, Rugarli EI, Langer T (2016) Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J. Cell Biol. 212: 157–166

2015
Richter-Dennerlein R, Dennerlein S, Rehling P (2015) Integrating mitochondrial translation into the cellular context. Nat. Rev. Mol. Cell Biol. 16: 586–592

2014
Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T (2014) DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling. Cell Metabolism 20: 158–171