Publications (since 2017)

2021
Lavdovskaia E, Hillen HS, Richter-Dennerlein R (2021) Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis. Trends Cell Biol , .

Bhatta A, Dienemann C, Cramer P, Hillen HS (2021) Structural basis of RNA processing by human mitochondrial RNase P. Nat Struct Mol Biol 28, 713-723.

Jochheim FA, Tegunov D, Hillen HS, Schmitzová J, Kokic G, Dienemann C, Cramer P (2021) The structure of a dimeric form of SARS-CoV-2 polymerase. Commun Biol 4, 999.

Kabinger F, Stiller C, Schmitzová J, Dienemann C, Kokic G, Hillen HS, Höbartner C, Cramer P (2021) Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat Struct Mol Biol 28, 740-746.

Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R (2021) Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nat Commun 12, 3672.

Hillen HS (2021) Structure and function of SARS-CoV-2 polymerase. Curr Opin Virol 48, 82-90.

Hillen HS, Markov DA, Wojtas ID, Hofmann KB, Lidschreiber M, Cowan AT, Jones JL, Temiakov D, Cramer P, Anikin M (2021) The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proc Natl Acad Sci U S A 118, .

Cramer P, Kokic G, Dienemann C, Höbartner C, Hillen HS (2021) Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir. Biospektrum (Heidelb) 27, 49-53.

Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P (2021) Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun 12, 279.

2020
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG (2020) Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588, 712-716.

Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P (2020) Structure of replicating SARS-CoV-2 polymerase. Nature 584, 154-156.

2019
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Hüttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Böttcher B, Szalay AA, Cramer P, Fischer U (2019) Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes. Cell 179, 1537-1550.e19.

Hillen HS, Bartuli J, Grimm C, Dienemann C, Bedenk K, Szalay AA, Fischer U, Cramer P (2019) Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes. Cell 179, 1525-1536.e12.

2018
Hillen HS, Temiakov D, Cramer P (2018) Structural basis of mitochondrial transcription. Nat Struct Mol Biol 25, 754-765.

2017
Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P (2017) Structural Basis of Mitochondrial Transcription Initiation. Cell 171, 1072-1081.e10.

Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D (2017) Mechanism of Transcription Anti-termination in Human Mitochondria. Cell 171, 1082-1093.e13.