Publications (since 2003)

2021
Lagadec F, Carlon-Andres I, Ragues J, Port S, Wodrich H, Kehlenbach RH (2021) CRM1 promotes capsid disassembly and nuclear envelope translocation of adenovirus independently of its export function. J Virol , JVI0127321.

James C, Kehlenbach RH (2021) The Interactome of the VAP Family of Proteins: An Overview. Cells 10, .

Baade I, Hutten S, Sternburg EL, Pörschke M, Hofweber M, Dormann D, Kehlenbach RH (2021) The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors. J Biol Chem 296, 100659.

Hamed M, Caspar B, Port SA, Kehlenbach RH (2021) A nuclear export sequence promotes CRM1-dependent targeting of the nucleoporin Nup214 to the nuclear pore complex. J Cell Sci 134, .

2020
Chizhik AI, Chizhik AM, Ruhlandt D, Pfaff J, Karedla N, Gregor I, Kehlenbach RH, Enderlein J (2020) Dual-Color Metal-Induced Energy Transfer (MIET) Imaging for Three-Dimensional Reconstruction of Nuclear Envelope Architecture. Methods Mol Biol 2175, 33-45.

Lavau CP, Aumann WK, Sze SK, Gupta V, Ripple K, Port SA, Kehlenbach RH, Wechsler DS (2020) The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice. PLoS One 15, e0232036.

Carlon-Andres I, Lagadec F, Pied N, Rayne F, Lafon ME, Kehlenbach RH, Wodrich H (2020) Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import. J Virol 94, .

Müller M, James C, Lenz C, Urlaub H, Kehlenbach RH (2020) Probing the Environment of Emerin by Enhanced Ascorbate Peroxidase 2 (APEX2)-Mediated Proximity Labeling. Cells 9, .

Ashkenazy-Titelman A, Shav-Tal Y, Kehlenbach RH (2020) Into the basket and beyond: the journey of mRNA through the nuclear pore complex. Biochem J 477, 23-44.

2019
James C, Müller M, Goldberg MW, Lenz C, Urlaub H, Kehlenbach RH (2019) Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane. J Biol Chem 294, 16241-16254.

Kindermann B, Valkova C, Krämer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C (2019) The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling. J Biol Chem 294, 11741-11750.

Blenski M, Kehlenbach RH (2019) Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane. Int J Mol Sci 20, .

Baade I, Kehlenbach RH (2019) The cargo spectrum of nuclear transport receptors. Curr Opin Cell Biol 58, 1-7.

2018
Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B (2018) Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence. PLoS Genet 14, e1007845.

Wu K, Wang L, Chen Y, Pirooznia M, Singh K, Wälde S, Kehlenbach RH, Scott I, Gucek M, Sack MN (2018) GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking. J Cell Sci 131, .

Komatsu T, Quentin-Froignant C, Carlon-Andres I, Lagadec F, Rayne F, Ragues J, Kehlenbach RH, Zhang W, Ehrhardt A, Bystricky K, Morin R, Lagarde JM, Gallardo F, Wodrich H (2018) In Vivo Labelling of Adenovirus DNA Identifies Chromatin Anchoring and Biphasic Genome Replication. J Virol 92, .

Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach RH, Bailer SM, Dormann D (2018) Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1. Sci Rep 8, 7084.

Baade I, Spillner C, Schmitt K, Valerius O, Kehlenbach RH (2018) Extensive Identification and In-depth Validation of Importin 13 Cargoes. Mol Cell Proteomics 17, 1337-1353.

2017
Chizhik AM, Ruhlandt D, Pfaff J, Karedla N, Chizhik AI, Gregor I, Kehlenbach RH, Enderlein J (2017) Three-Dimensional Reconstruction of Nuclear Envelope Architecture Using Dual-Color Metal-Induced Energy Transfer Imaging. ACS Nano 11, 11839-11846.

2016
Port SA, Mendes A, Valkova C, Spillner C, Fahrenkrog B, Kaether C, Kehlenbach RH (2016) The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export. J Biol Chem 291, 23068-23083.

Landry-Voyer AM, Bilodeau S, Bergeron D, Dionne KL, Port SA, Rouleau C, Boisvert FM, Kehlenbach RH, Bachand F (2016) Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors. Mol Cell Biol 36, 3019-3032.

Kehlenbach RH, Port SA (2016) Analysis of CRM1-Dependent Nuclear Export in Permeabilized Cells. Methods Mol Biol 1411, 489-501.

Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E (2016) Distinct functions of the dual leucine zipper kinase depending on its subcellular localization. Cell Signal 28, 272-283.

Pfaff J, Rivera Monroy J, Jamieson C, Rajanala K, Vilardi F, Schwappach B, Kehlenbach RH (2016) Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane. J Cell Sci 129, 502-516.

2015
Monecke T, Dickmanns A, Weiss MS, Port SA, Kehlenbach RH, Ficner R (2015) Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex. Acta Crystallogr F Struct Biol Commun 71, 1481-1487.

Dickmanns A, Kehlenbach RH, Fahrenkrog B (2015) Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease. Int Rev Cell Mol Biol 320, 171-233.

Port SA, Monecke T, Dickmanns A, Spillner C, Hofele R, Urlaub H, Ficner R, Kehlenbach RH (2015) Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep 13, 690-702.

Halder K, Dölker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubmüller H, Neumann H (2015) MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β. Biophys J 109, 277-286.

2014
Kimura M, Thakar K, Karaca S, Imamoto N, Kehlenbach RH (2014) Novel approaches for the identification of nuclear transport receptor substrates. Methods Cell Biol 122, 353-378.

Furuta M, Kose S, Kehlenbach RH, Imamoto N (2014) Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions. Methods Cell Biol 122, 331-352.

Frohnert C, Hutten S, Wälde S, Nath A, Kehlenbach RH (2014) Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase. PLoS One 9, e88887.

2013
Schulz O, Pieper C, Clever M, Pfaff J, Ruhlandt A, Kehlenbach RH, Wouters FS, Großhans J, Bunt G, Enderlein J (2013) Resolution doubling in fluorescence microscopy with confocal spinning-disk image scanning microscopy. Proc Natl Acad Sci U S A 110, 21000-21005.

Snow CJ, Dar A, Dutta A, Kehlenbach RH, Paschal BM (2013) Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport. J Cell Biol 201, 541-557.

Roloff S, Spillner C, Kehlenbach RH (2013) Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1. J Biol Chem 288, 3952-3963.

Thakar K, Karaca S, Port SA, Urlaub H, Kehlenbach RH (2013) Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry. Mol Cell Proteomics 12, 664-678.

Ehlers C, Schirmer S, Kehlenbach RH, Hauber J, Chemnitz J (2013) Post-transcriptional regulation of CD83 expression by AUF1 proteins. Nucleic Acids Res 41, 206-219.

2012
Malik P, Tabarraei A, Kehlenbach RH, Korfali N, Iwasawa R, Graham SV, Schirmer EC (2012) Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways. J Biol Chem 287, 12277-12292.

Waldmann I, Spillner C, Kehlenbach RH (2012) The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent nuclear protein export. J Cell Sci 125, 144-154.

Wälde S, Thakar K, Hutten S, Spillner C, Nath A, Rothbauer U, Wiemann S, Kehlenbach RH (2012) The nucleoporin Nup358/RanBP2 promotes nuclear import in a cargo- and transport receptor-specific manner. Traffic 13, 218-233.

2011
Hamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, Wälde S, Joseph J, Kehlenbach RH, van Deursen JM (2011) Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol 194, 597-612.

Pieper D, Schirmer S, Prechtel AT, Kehlenbach RH, Hauber J, Chemnitz J (2011) Functional characterization of the HuR:CD83 mRNA interaction. PLoS One 6, e23290.

2010
Wälde S, Kehlenbach RH (2010) The Part and the Whole: functions of nucleoporins in nucleocytoplasmic transport. Trends Cell Biol 20, 461-469.

Hilliard M, Frohnert C, Spillner C, Marcone S, Nath A, Lampe T, Fitzgerald DJ, Kehlenbach RH (2010) The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. J Biol Chem 285, 22202-22210.

Huenniger K, Krämer A, Soom M, Chang I, Köhler M, Depping R, Kehlenbach RH, Kaether C (2010) Notch1 signaling is mediated by importins alpha 3, 4, and 7. Cell Mol Life Sci 67, 3187-3196.

2009
Antony PM, Mäntele S, Mollenkopf P, Boy J, Kehlenbach RH, Riess O, Schmidt T (2009) Identification and functional dissection of localization signals within ataxin-3. Neurobiol Dis 36, 280-292.

Hutten S, Wälde S, Spillner C, Hauber J, Kehlenbach RH (2009) The nuclear pore component Nup358 promotes transportin-dependent nuclear import. J Cell Sci 122, 1100-1110.

2008
Hutten S, Flotho A, Melchior F, Kehlenbach RH (2008) The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. Mol Biol Cell 19, 2300-2310.

2007
Waldmann I, Wälde S, Kehlenbach RH (2007) Nuclear import of c-Jun is mediated by multiple transport receptors. J Biol Chem 282, 27685-27692.

Hutten S, Kehlenbach RH (2007) CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol 17, 193-201.

Fries B, Heukeshoven J, Hauber I, Grüttner C, Stocking C, Kehlenbach RH, Hauber J, Chemnitz J (2007) Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression. J Biol Chem 282, 4504-4515.

2006
Hutten S, Kehlenbach RH (2006) Nup214 is required for CRM1-dependent nuclear protein export in vivo. Mol Cell Biol 26, 6772-6785.

Arnold M, Nath A, Hauber J, Kehlenbach RH (2006) Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. J Biol Chem 281, 20883-20890.

Schütz S, Chemnitz J, Spillner C, Frohme M, Hauber J, Kehlenbach RH (2006) Stimulated expression of mRNAs in activated T cells depends on a functional CRM1 nuclear export pathway. J Mol Biol 358, 997-991009.

Prechtel AT, Chemnitz J, Schirmer S, Ehlers C, Langbein-Detsch I, Stülke J, Dabauvalle MC, Kehlenbach RH, Hauber J (2006) Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element. J Biol Chem 281, 10912-10925.

Arnold M, Nath A, Wohlwend D, Kehlenbach RH (2006) Transportin is a major nuclear import receptor for c-Fos: a novel mode of cargo interaction. J Biol Chem 281, 5492-5499.

2003
Kehlenbach RH (2003) In vitro analysis of nuclear mRNA export using molecular beacons for target detection. Nucleic Acids Res 31, e64.